Publications related to Transition (genetics)

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Bart Deplancke, Andreas Massouras, Sandy Lee, Yi Han, Yiming Zhu

The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used a ...

Cold Spring Harbor Laboratory Press2014

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Jacques Fellay, Amalio Telenti

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated fact ...

Oxford University Press2013

Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster

Bart Deplancke, Sebastian Martin Waszak, Andreas Massouras, Jeffrey David Jensen, Monica Albarca Aguilera

Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here ...

Public Library of Science2012

Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity

John McKinney, Swapna Uplekar, Anna De Graff Tischler

Onset of the adaptive immune response in mice infected with Mycobacterium tuberculosis is accompanied by slowing of bacterial replication and establishment of a chronic infection. Stabilization of bacterial numbers during the chronic phase of infection is ...

2011

Model Structure of Human APOBEC3G

Didier Trono, Bastien Mangeat, Amalio Telenti, Olivier Michielin

BACKGROUND: APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) has antiretroviral activity associated with the hypermutation of viral DNA through cytosine deamination. APOBEC3G has two cytosine deaminase (CDA) domains; the catal ...

Public Library of Science2007

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS

Didier Trono, Bastien Mangeat, Amalio Telenti

The cytosine deaminase APOBEC3G, in the absence of the human immunodeficiency virus type 1 (HIV-1) accessory gene HIV-1 viral infectivity factor (vif), inhibits viral replication by introducing G-->A hypermutation in the newly synthesized HIV-1 DNA negativ ...

American Society for Microbiology2004

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Transition (genetics)

Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster

Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity

Model Structure of Human APOBEC3G

A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: A cohort allelic sums test (CAST)

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS

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Chat with Graph Search

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: A cohort allelic sums test (CAST)

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS

Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster

Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity

Model Structure of Human APOBEC3G