Concept
Addiction
Related publications (75)
Impact of Mitofusin 2 in the Nucleus Accumbens on motivated behavior and underlying neurobiological mechanisms
The nucleus accumbens (NAc) is part of the ventral striatum and plays a major role in motivation and goal-directed behaviour. Increasing evidence implicates impairments in accumbal function in anxiety and depression, two conditions that are commonly accomp ...
EPFL2024Striatal Dopamine Signals and Reward Learning
Carl Petersen, Sylvain Crochet, Yanqi Liu, Parviz Ghaderi, Mauro Pulin, Anthony Pierre Robert Renard, Christos Sourmpis, Pol Bech Vilaseca, Meriam Malekzadeh, Robin François Virginien Dard
We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...
Oxford2023GABAergic-like dopamine synapses in the brain
Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance, the true biological nature of dopamine synap ...
Cambridge2023Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function
Maria del Carmen Sandi Perez, Bernard Schneider, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Marie-Isabelle Guillot de Suduiraut, Alessandro Chioino, Sriparna Ghosal, Eva Ramos Fernandez
The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...
2023Successful MRI-Guided Focused Ultrasound Thalamotomy after Ipsilateral Gamma Knife Radiosurgery for Essential Tremor: A Case Report with Video
Constantin Tuleasca, David Paul Roger Romascano, Damien Schneider
We report the case of a 67-year-old left-handed female patient with disabling medically refractory essential tremor who underwent successful right-sided magnetic resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate nucleus after ipsilat ...
Basel2023Reward timing matters in motor learning
Pierre Theopistos Vassiliadis, Julie Duqué
Reward timing, that is, the delay after which reward is delivered following an action is known to strongly influence reinforcement learning. Here, we asked if reward timing could also modulate how people learn and consolidate new motor skills. In 60 health ...
CELL PRESS2022Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Ioannis Zalachoras, Mandy Meijer
Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...
2022Dopamine Dynamics in Reward-based Learning
Dopamine signals are thought to be important for reward-based learning and appear to play important roles in regulating synaptic plasticity in the nucleus accumbens and the striatum. However, the precise neuronal circuit mechanisms underlying the learning ...
EPFL2022Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity
Bernard Schneider, Akhil Sharma
Methamphetamine (METH) is a highly abused psychostimulant that is neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases the risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated ...
MDPI2022Secure and Federated Genome-Wide Association Studies for Biobank-Scale Datasets
Jean-Pierre Hubaux, Juan Ramón Troncoso-Pastoriza, Apostolos Pyrgelis, Jeffrey Chen, David Jules Froelicher
Sharing data across multiple institutions for genome-wide association studies (GWAS) would enable discovery of novel genetic variants linked to health and disease. However, existing regulations on genomic data sharing and the sheer size of the data limit t ...
2022