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Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man-TLR7), which, when conjugated to antige ...
Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...
The analysis of air bubbles trapped in polar ice has permitted the reconstruction of past atmospheric concentrations of CO2 over various timescales, and revealed that large climate changes over tens of thousands of years are generally accompanied by change ...
Testate amoebae are informative about palaeoecological conditions, but the methods generally used for their analyses in lake sediments differ from those used for their analyses in peats, making comparisons difficult. This study examines how filter mesh siz ...
This experimental programme employs length-scale analysis of measured profiles to quantitatively discriminate the surface textures of stone flakes manufactured from East Anglian chalk flint used on four contact materials (shell, wood, dry hide and soaked a ...
A comparison of relevant properties of selected pyranosyl-RNA and homo-DNA duplexes offers an opportunity for testing the thesis of the predominant role of inter-strand base stacking in oligonucleotide systems with large backbone inclination. Missing base ...
Atmospheric methane (CH4) records reconstructed from polar ice cores represent an integrated view on processes predominantly taking place in the terrestrial biogeosphere. Here, we present dual stable isotopic methane records [δ13CH4 and δD(CH4)] from four ...
Proceedings of the National Academy of Sciences2007
