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Related publications (26)
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal
Microvascular stalling, the process occurring when a capillary temporarily loses perfusion, has gained increasing interest in recent years through its demonstrated presence in various neuropathologies. Studying the impact of such stalls on the surrounding ...
2023Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...
NATURE PORTFOLIO2022FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
Mauro Delorenzi, Alexis Rapin, Dominique Velin, Esther Bovay, François Renevey
The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...
AMER ASSOC ADVANCEMENT SCIENCE2021Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma
Paul Joseph Dyson, Etienne Meylan, Julien Robert Rémi Faget, Aspasia Gkasti, Yameng Hao, Maxime Reichenbach
OBJECTIVES: Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Approaches to enhance patient immunity against MPM have been tested but shown variable results. Previously, we have demonstrated interesting vascular modul ...
OXFORD UNIV PRESS INC2020Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain
Firstly, this thesis presents the in vivo evaluation of a previously developed model system that utilizes CD4+ TE/M cells decorated with up to 100 polystyrene based nanoparticles per cell by maleimide thiol conjugation. These nanoparticle T-cell conjugates ...
EPFL2020A novel culture method that sustains ER alpha signaling in human breast cancer tissue microstructures
Cathrin Brisken, Georgios Sflomos
Background Estrogen receptor alpha (ER alpha) signaling is a defining and driving event in most breast cancers; ER alpha is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these cases, E ...
2020Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans
Laurent Gillet, Christian Sieben
Virus infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by interactions between viral proteins and cell-surface receptors. Various cell-surface glycans func ...
ANNUAL REVIEWS2020Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations
Philippe Renaud, George Coukos, Thamani Dahoun, Margaux Catherine Marie Duchamp, Alexandre Harari, Marion Arnaud
In this study we present a novel microfluidic hydrodynamic trapping device to probe the cell–cell interaction between all cell samples of two distinct populations. We have exploited an hydrodynamic trapping method using microfluidics to immobilize a batch ...
2019Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes
Harm-Anton Klok, Solenne Desseaux
Thin, thermoresponsive polymer coatings that allow to reversibly modulate cell adhesion and detachment are attractive substrates for cell sheet engineering. Usually, this is accomplished by applying thin poly(N-isopropylacrylamide) (PNIPAM) coatings, which ...
American Chemical Society2014Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays
Recruitment of leukocytes from blood to tissues is a multi-step process playing a major role in the activation of inflammatory responses. Tethering and rolling of leukocytes along the vessel wall, followed by arrest and transmigration through the endotheli ...
Elsevier2013