Concept

Onchocerciasis

Related publications (13)

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

NATURE PUBLISHING GROUP2020

Clinical relevance of low-densityPlasmodium falciparumparasitemia in untreated febrile children: A cohort study

Mary-Anne Hartley

Background Low-density (LD)Plasmodiuminfections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study i ...

2020

In vivo electrical stimulation of the optic nerve and hybrid computational model for neuroprosthetic applications

Silvestro Micera, Diego Ghezzi, Samuel Charles Antoine Gilliéron, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet

Blindness affects millions of people worldwide, dramatically decreasing their quality of life. Retinal dystrophies, such as age related macular degeneration and Retinitis Pigmentosa, which are leading causes of blindness in industrialized countries, curren ...

2018

Virus transfer at the skin-liquid interface and its associated risks

Ana Karina Pitol Garcia

Infectious diseases are a leading cause of death across the world. One of the primary causes of infectious diseases are viruses. Since liquids are highly important in the transmission of viruses, the aims of this work are to i) quantify the transfer of vir ...

EPFL2018

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

Luc Xavier Marie Lebon

Intestinal helminth infections are a global health problem affecting particularly people living in poor countries. Heavy worm burdens can lead to nutritional and cognitive deficiencies. Type-two immunity plays a crucial role in promoting tissue repair and ...

EPFL2017

A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness

Diego Ghezzi

The degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no e ...

2017

A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness

Diego Ghezzi

The degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of retinal degenerative disorders. Here we report on the fabrication and functi ...

Nature Publishing Group2017

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis

Stewart Cole

Background Mycetoma is a neglected, chronic, and deforming infectious disease caused by fungi and actinomycetes. In Mexico, N. brasiliensis is the predominant etiologic agent. Therapeutic alternatives are necessary because the current drug regimens have se ...

Public Library of Science2015

Advances in helminth immunology: optimism for future vaccine design?

Nicola Harris

Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate with disease morbidity and children generally harbor the largest numbers. The majority of intestinal helminths do not replicate within their host, and worm burdens ...

2011

Simulation of the Outflow Pathway in the Human Eye

Nikolaos Stergiopoulos, Sylvain Roy, Philippe Reymond, Andreas Schmocker, Orestis Vardoulis

The eye structure and function highly depend on the stability of the intraocular pressure (IOP). Glaucoma is an ophthalmic disease that can potentially lead to irreversible blindness. Glaucoma results from optic nerve damages due to persistent elevated IOP ...

Springer, 233 Spring Street, New York, Ny 10013, United States2010

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