Concept

Genetic variability

Related publications (114)

HIV host genomics in the era of effective antiretroviral therapy

The introduction and widespread use of antiretroviral therapy against Human Immunodefi-ciency Virus (HIV) has had a remarkable effect on disease progression and the longevity of infected individuals. However, the establishment of a latent viral reservoir a ...

EPFL2020

Trustworthy Face Recognition: Improving Generalization of Deep Face Presentation Attack Detection

Amir Mohammadi

The extremely high recognition accuracy achieved by modern, convolutional neural network (CNN) based face recognition (FR) systems has contributed significantly to the adoption of such systems in a variety of applications, from mundane activities like unlo ...

EPFL2020

Genetic variation and evolutionary history of a mycorrhizal fungus regulate the currency of exchange in symbiosis with the food security crop cassava

Romain Savary, Cindy Dupuis

Most land plants form symbioses with arbuscular mycorrhizal fungi (AMF). Diversity of AMF increases plant community productivity and plant diversity. For decades, it was known that plants trade carbohydrates for phosphate with their fungal symbionts. Howev ...

2020

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Anne-Florence Raphaëlle Bitbol, Loïc Marrec

We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...

2020

Signatures of coherent flow structures in the atmospheric surface layer over Lake Geneva

David Andrew Barry, Ulrich Lemmin, Mehrshad Foroughan

Reliable estimates of air-water exchange of momentum, heat, and gas are vital for understanding boundary layer dynamics and for developing accurate global and regional climate and weather forecasting models. Spatiotemporal variability of physical processes ...

2020

Improving Inter-Laboratory Reproducibility in Measurement of Biochemical Methane Potential (BMP)

Christof Holliger

Biochemical methane potential (BMP) tests used to determine the ultimate methane yield of organic substrates are not sufficiently standardized to ensure reproducibility among laboratories. In this contribution, a standardized BMP protocol was tested in a l ...

2020

TASH: Toolbox for the Automated Segmentation of Heschl's gyrus

Dimitri Nestor Alice Van De Ville

Auditory cortex volume and shape differences have been observed in the context of phonetic learning, musicianship and dyslexia. Heschl's gyrus, which includes primary auditory cortex, displays large anatomical variability across individuals and hemispheres ...

2020

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

Giovanna Ambrosini, Philipp Bucher, Amit Sharma, Tikam Chand Dakal

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of alpha-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants link ...

Springer2019

Chromatin three-dimensional interactions mediate genetic effects on gene expression

David Hacker, Giovanna Ambrosini, Philipp Bucher, Sanjeev Kumar

Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a da ...

2019

Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch

The variability in transcription factor concentration among cells is an important developmental determinant, yet how variability is controlled remains poorly understood. Studies of variability have focused predominantly on monitoring mRNA production noise. ...

The Company of Biologists2019

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