Concept

Stereoisomerism

Related publications (99)

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. On ...

2008

The role of Hox genes during vertebrate limb development

Denis Duboule, Jozsef Zakany

The potential role of Hox genes during vertebrate limb development was brought into focus by gene expression analyses in mice (P Dolle, JC Izpisua-Belmonte, H Falkenstein, A Renucci, D Duboule, Nature 1989, 342:767-772), at a time when limb growth and patt ...

2007

Aziridinium from N,N-dibenzyl serine methyl ester: Synthesis of enantiomerically pure beta -amino and alpha ,beta -diamino esters

Jieping Zhu

Reaction of N,N-dibenzyl-O-methylsulfonyl serine Me ester with a variety of heteronucleophiles (sodium azide, sodium phthalimide, amines, thiols) and carbanions (sodium malonate) gave, via an aziridinium intermediate, the corresponding beta -amino or alpha ...

2006

Isomerization mechanisms of a labile Co(II) octahedral complex

André Merbach, Lothar Helm, Fabrice Riblet

The labile cobalt (II) complex [Co(TUF)2(Pic)2] with 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (TUF) bidentate and 4-methylpyridine (Pic) monodentate ligands was studied by variable temp. (VT) 19F NMR from 184 to 312 K. In contrast to the solid state, ...

2006

Asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397

Pierre Vogel, Sandrine Gerber, Kai Torsten Meilert

A total asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397 was developed through the stereoselective functionalization of (1R,1’S,6S,6’R)-3,3’-methylenebis(cyclohept-3-ene-1,6-diol). The pathway generates a large variety ...

2006

The conformational behavior of novel glycosidase inhibitors with substituted azepan structures: An NMR and modeling study

Pierre Vogel, Eliazar Rodriguez Garcia

The conformational analysis of a series of configurational isomers of 2-(hydroxymethyl)azepan-3,4,5,6-tetrols 1-4 has been carried out. H-1 NMR spectroscopic data, especially vicinal J couplings and nuclear Overhauser enhancements (NOE), assisted by molecu ...

2004

Isomer specific spectroscopy of metal clusters trapped in a matrix: Ag9

Wolfgang Harbich, Christoph Sieber

Clusters of metal atoms at a fixed size can assume different structural arrangements, known as isomers, which may have nearly the same energy. Therefore at given experimental conditions distribution of these isomers can be present. While the size selection ...

2004

Catalytic hydrogenation by triruthenium clusters: A mechanistic study with parahydrogen-induced polarization

Paul Joseph Dyson

The reactivity of the cluster family [Ru-3(CO)(12-x)(L)x] (in which L = PMe3, PMe2Ph, PPh3 and PCy3, x = 1 - 3) towards hydrogen is described. When x=2, three isomers of [Ru-3(H)(mu-H)(CO)(9)(L)(2)] are formed, which differ in the arrangement of their equa ...

2003

Perhydrocarbyl Re-VII complexes: Comparison of molecular and surface complexes

David Lyndon Emsley

The molecular complex [Re(equivalent toC(t)Bu)(=(CHBu)-Bu-t)((CH2Bu)-Bu-t)2] (1) reacts with a silica partially dehydroxylated at 700 degreesC to give syn-2, [(equivalent toSiO)Re(equivalent toC(t)Bu)(=(CHBu)-Bu-t)((CH2Bu)-Bu-t)], as a single isomer accord ...

AMER CHEMICAL SOC2003

Syntheses of beta-C(1 -> 3)-Glucopyranosides of 2-and 4-deoxy-D-hexoses

Pierre Vogel, Raynald Demange

The Oshima-Nozaki (Et2AlI) condensation of isolevoglucosenone (4) with 2,6-anhydro-3,4,5,7-tetra-O-benzyl-D-glycero-D-gulo-heptose (5) gave an enone 6 that was converted with high stereoselectivity to 3-C-[(IR)-2,6-anhydro-D-glycero-D-gulo-heptitol-1-C-yl] ...

2003

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