Concept
Habenula
Related publications (33)
Unveiling the complexity of learning and decision-making
Reinforcement learning (RL) is crucial for learning to adapt to new environments. In RL, the prediction error is an important component that compares the expected and actual rewards. Dopamine plays a critical role in encoding these prediction errors. In my ...
EPFL2024Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort
Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, Simone Astori, João Pedro de Matos Rodrigues, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Alina Veronika Irene Strasser, Eva Ramos Fernandez
Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...
2022Increased Gray Matter Density in the Right Mesencephalic Tegmentum Is Associated With Better Engel Classes I and II After Radiosurgery for Hypothalamic Hamartomas
BACKGROUND:Hypothalamic hamartomas (HHs) are disabling congenital lesions, responsible for gelastic seizures frequently associated with catastrophic epilepsies, epileptogenic encephalopathy, and cognitive and psychiatric severe comorbidities. Stereotactic ...
LIPPINCOTT WILLIAMS & WILKINS2022Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Ioannis Zalachoras, Mandy Meijer
Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...
2022