Concept

RNA editing

Related publications (156)

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

Nanopore sensing is a single-molecule technique that allows to probe the nano-bio-world with accuracy. It is a non-invasive technique, which means that the molecule of interest does not need to be labeled to be detected by the nanopore. Most of the studies ...

EPFL2012

Dual Lineage-Specific Expression of Sox17 During Mouse Embryogenesis

Marine Marie Kraus, Anne Grapin-Botton, Laurence Anne E Lemaire

Sox17 is essential for both endoderm development and fetal hematopoietic stem cell (HSC) maintenance. While endoderm-derived organs are well known to originate from Sox17-expressing cells, it is less certain whether fetal HSCs also originate from Sox17-exp ...

Wiley-Blackwell2012

Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis

Stewart Cole, Jacques Rougemont, Claudia Sala, Ruben Hartkoorn, Philippe Busso, Swapna Uplekar

In Mycobacterium tuberculosis the alternative sigma factor SigF controls the expression of a particular subset of genes by altering RNA polymerase specificity. Here, we utilize two genome-wide approaches to identify SigF-binding sites: chromatin immunoprec ...

2012

The corrinoid metabolism in desulfitobacterium hafniense - genetic and regulatory aspects

Christof Holliger, Julien Maillard, Emmanuelle Rohrbach, Aurélie Duret

Corrinoids (e.g. vitamin B12, cobalamin) represent a family of complex organometallic cofactors essential to the metabolism of microorganisms, animal and humans, and are involved in several enzymes such as isomerases, methyltransferases and reductive dehal ...

2012

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Jacques Fellay, Amalio Telenti, Istvan Bartha

Background: The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of select ...

2011

Widespread occurrence of non-canonical transcription termination by human RNA polymerase III

Human RNA polymerase (Pol) III-transcribed genes are thought to share a simple termination signal constituted by four or more consecutive thymidine residues in the coding DNA strand, just downstream of the RNA 3'-end sequence. We found that a large set of ...

Oxford University Press2011

In Vivo Studies on the Control of Gene Expression and Protein Degradation

Karolina Bojkowska

Cellular homeostasis is maintained by tightly regulated gene networks, controlled notably at the levels of transcription, mRNA processing, and protein post-translational modification and turnover. This thesis focuses on two of these regulatory steps, namel ...

EPFL2011

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

Joachim Lingner, Sophie Redon

Telomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms an integral part of telomeric heterochromatin. TERRA molecules resemble in sequence ...

Oxford University Press2010

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Ozgün Gökce, Heike Runne

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves ...

National Academy of Sciences2010

Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Didier Trono, Priscilla Turelli, Amalio Telenti, Shyam Sunder Peddi, Olivier Michielin

Members of the human APOBEC3 family of editing enzymes can inhibit various mobile genetic elements. APOBEC3A (A3A) can block the retrotransposon LINE-1 and the parvovirus adeno-associated virus type 2 (AAV-2) but does not inhibit retroviruses. In contrast, ...

American Society for Microbiology2010

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.