Concept

Anxiolytic

Related publications (32)

Motor Control in the Mouse Whisker System

The motor systems of the mammalian brain are a remarkable product of many millions of years of evolution. It is the motor systems that make us and other mammals mobile, that guide our actions in response to sensory information and conversely modulate the v ...

EPFL2015

Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implica ...

Public Library of Science2014

Visual backward masking deficits in schizotypy are observed in late but not early onset nicotine smokers

Michael Herzog, Christine Mohr, Guillaume Sierro, Géraldine Beaud

Visual backward masking (VBM) is a potential endophenotype for schizophrenia. Relative VBM deficits were also observed in high as compared to low scorers in one schizotypal subdimension (cognitive disorganisation, CogDis; Cappe et al., 2012). VBM deficits ...

2014

Personality traits in rats predict vulnerability and resilience to developing stress-induced depression-like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Cristina Marquez Vega, Jorge Eduardo Castro Cifuentes, Shanaz Diessler

Emerging evidence indicates that certain behavioral traits, such as anxiety, are associated with the development of depression-like behaviors after exposure to chronic stress. However, single traits do not explain the wide variability in vulnerability to s ...

Elsevier2012

Psychobiological Vulnerability to Stress

Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes

Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...

EPFL2012

Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries

Grégoire Courtine, Pavel Musienko, Rubia van den Brand

Descending monoaminergic inputs markedly influence spinal locomotor circuits, but the functional relationships between specific receptors and the control of walking behavior remain poorly understood. To identify these interactions, we manipulated serotoner ...

2011

Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin

Rolf Gruetter

Cerebral rates of anaplerosis are known to be significant, yet the rates measured in vivo have been debated. In order to track glutamate metabolism in brain glutamatergic neurons and brain glia, for the first time unrestrained awake rats were continuously ...

Wiley-Blackwell2004

Antidepressant medication and the assimilation of problematic experiences in psychotherapy

Michael Christoph Gastpar

The authors assessed whether the psychotherapeutic process is enhanced by the addition of antidepressant medication. Mildly to moderately depressed patients received client-centered therapy with or without medication. Patients were assessed for symptoms of ...

2003

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

Steinunn Baekkeskov Hanahan

The larger isoform of the enzyme glutamate decarboxylase, GAD67, synthesizes >90% of basal levels of γ-aminobutyric acid (GABA) in the brain. In contrast, the smaller isoform, GAD65, has been implicated in the fine-tuning of inhibitory neurotransmission. M ...

National Academy of Sciences1999

Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells

Steinunn Baekkeskov Hanahan

Although expressed at very low levels in islets of NOD mice, GAD65 is a candidate islet autoantigen. Two transgenic lines of NOD/Lt mice expressing high levels of human GAD65 from a rat insulin promoter were generated. Transgenes were integrated on proxima ...

American Diabetes Association1998

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