Publications related to Maprotiline

Multivariate patterns of disrupted sleep longitudinally predict affective vulnerability to psychosis in 22q11.2 Deletion Syndrome

Maude Schneider, Farnaz Delavari

22q11.2 deletion syndrome (22q11DS) contributes dramatically to increased genetic risk for psychopathology, and in particular schizophrenia. Sleep disorders, including obstructive sleep apnea (OSA), are also highly prevalent, making 22q11DS a unique model ...

ELSEVIER IRELAND LTD2023

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-René Cardinaux

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...

Nature Publishing Group2016

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Douglas Hanahan, Ksenya Shchors, Aristea Massaras

The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and elevated autophagy in glioma cells motivated investigation in mouse models of gliomagenesis. First, we established that imipramine, a TCA, increased autophagy and co ...

Elsevier2015

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Pierre Magistretti, Jean-Luc Martin, Igor Allaman

There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of ...

Bentham Science Publishers2013

Psychobiological Vulnerability to Stress

Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes

Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...

EPFL2012

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Maria del Carmen Sandi Perez, Reto Bisaz

Critical interactions between genetic and environmental factors -- among which stress is one of the most potent non-genomic factors -- are involved in the development of mood disorders. Intensive work during the past decade has led to the proposal of the n ...

Karger2007

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Maprotiline

Multivariate patterns of disrupted sleep longitudinally predict affective vulnerability to psychosis in 22q11.2 Deletion Syndrome

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Psychobiological Vulnerability to Stress

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Chemical and physiological aspects of the actions of lithium and antidepressant drugs

Graph Chatbot

Chat with Graph Search

Chemical and physiological aspects of the actions of lithium and antidepressant drugs

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Psychobiological Vulnerability to Stress

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Multivariate patterns of disrupted sleep longitudinally predict affective vulnerability to psychosis in 22q11.2 Deletion Syndrome

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme