Concept

Osteopontin

Related publications (32)

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Anders Meibom, Jaroslaw Hubert Stolarski, Jinming Guo

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

NATURE PORTFOLIO2023

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari, Tatiana Kochetkova

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

Biological responses at the interface of Ti-doped diamond-like carbon surfaces for indoor environment application

Sami Rtimi

Diamond-like carbon (DLC) and titanium-doped DLC coatings were prepared by hybrid PECVD/direct current magnetron sputtering (DCMS). In this study, we show that the operating conditions of titanium-doped DLC coatings used for implants in surgical devices si ...

SPRINGER HEIDELBERG2020

Structural description of surfaces and interfaces in biominerals by DNP SENS

David Lyndon Emsley, David Benjamin Roger Antoine Gajan

Biological mineralized tissues are hybrid materials with complex hierarchical architecture composed of biominerals often embedded in an organic matrix. The atomic-scale comprehension of surfaces and organo-mineral interfaces of these biominerals is of para ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

Flexoelectricity in Bones

Dragan Damjanovic

Bones generate electricity under pressure, and this electromechanical behavior is thought to be essential for bone’s self-repair and remodeling properties. The origin of this response is attributed to the piezoelectricity of collagen, which is the main str ...

2018

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

PPAR beta/delta activation of CD300a controls intestinal immunity

Johan Auwerx

Macrophages are important for maintaining intestinal immune homeostasis. Here, we show that PPAR beta/delta (peroxisome proliferator-activated receptor beta/delta) directly regulates CD300a in macrophages that express the immunoreceptor tyrosine based-inhi ...

Nature Publishing Group2014

Compounds for functionalizing biomaterials

Sandrine Gerber, Françoise Borcard

The present invention provides compounds suitable for functionalizing biomaterials, in particular prosthetics and implant materials, functionalized biomaterials, and methods for synthesizing the compound. The compounds contain an anchoring group, a group f ...

2014

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

Ulrike Kettenberger

Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...

EPFL2014

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Jeffrey Alan Hubbell, Mikaël Martino

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

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