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For uninterrupted traffic flow, it is well-known that the fundamental diagram (FD) describes the relationship between traffic flow and density under steady state. For interrupted traffic flow on a signalized road, it has been recognized that the arterial f ...
Cultured fibroblasts adhere to extracellular substrates by means of cell-matrix adhesions that are assembled in a hierarchical way, thereby gaining in protein complexity and size. Here we asked how restricting the size of cell-matrix adhesions affects cell ...
Organohalide respiration (OHR) is a bacterial anaerobic energy metabolism that uses many chlorinated organic compounds as terminal electron donors. The process is catalyzed by a class of complex redox enzymes called reductive dehalogenases which harbour a ...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder which severely impairs cognitive functions by triggering neuronal cell death and synaptic loss, and finally leads the patients to death. Two main histopathological hallmarks can be found ...
Sensory adaptation reflects the fact that the responsiveness of a perceptual system changes after the processing of a specific stimulus. Two manifestations of this property have been used in order to infer the mechanisms underlying vision: priming, in whic ...
Association for Research in Vision and Ophthalmology2011
During mild heat-stress, a native thermolabile polypeptide may partially unfold and transiently expose water-avoiding hydrophobic segments that readily tend to associate into a stable misfolded species, rich in intra-molecular non-native beta-sheet structu ...
Biomaterials are increasingly being developed as in vitro microenvironments mimicking in vivo stem cell niches. However, current macroscale methodologies to produce these niche models fail to recapitulate the spatial and temporal characteristics of the com ...
Many G protein-coupled receptors (GPCRs) are known to form dimers or even oligomers, and these aggregated states have been proposed as functional units responsible for signal transduction and G protein activation. However, the nature of their involvement h ...
Organizations exploit the information diffusion and signaling properties of their existing inter-organizational networks to manage the risks and uncertainty involved in forming new partnerships. How then do new organizations that are unknown to existing ne ...
The mechanism of signal transduction in G-protein-coupled receptors (GPCRs) is a crucial step in cell signaling. However, the molecular details of this process are still largely undetermined. Carrying out submicrosecond molecular dynamics simulations of be ...