Concept

Southern blot

Related publications (92)

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

Although mycobacteria are known to accumulate polyphosphate (PolyP), a linear polymer of orthophosphate, when subjected to stresses, the exact roles of this molecule are not yet clearly understood. We found that deletion of the pstA gene encoding for a tra ...

EPFL2013

Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damage

Yohan Van de Looij

Intrauterine infection and inflammation are major reasons for preterm birth. The switch from placenta-mediated to lung-mediated oxygen supply during birth is associated with a sudden rise of tissue oxygen tension that amounts to relative hyperoxia in prete ...

Public Library of Science2012

The Regulatory Network of Natural Competence and Transformation of Vibrio cholerae

Melanie Blokesch, Mirella Lo Scrudato

The human pathogen Vibrio cholerae is an aquatic bacterium frequently encountered in rivers, lakes, estuaries, and coastal regions. Within these environmental reservoirs, the bacterium is often found associated with zooplankton and more specifically with t ...

2012

Activin Signalling in Human Melanoma Cells

Susanna Eveliina Kallioinen

Melanoma, the most fatal of all skin cancers, by unknown mechanisms overcomes the cytostatic effects of TGFβ, while maintaining the TGFβ signaling needed for its tumor promoting functions. Besides TGFβ, ectopic induction of the TGFβ family member Nodal has ...

EPFL2012

MicroRNA profiling by simultaneous selective isotachophoresis and hybridization with molecular beacons

Alexandre Louis André Persat

We present and demonstrate a novel assay for the detection and quantification of microRNA (miRNA) that leverages isotachophoresis (ITP) and molecular beacon (MB) hybridization. We use ITP to selectively preconcentrate miRNA from total RNA. We simultaneousl ...

American Chemical Society2011

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Pierre Magistretti, Igor Allaman, Thierry Laroche, Jean-Marie Petit, Jiangyan Yang

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011

Capacitance DNA bio-chips improved by new probe immobilization strategies

Giovanni De Micheli, Sandro Carrara, Yusuf Leblebici, Luca Benini, Andrea Cavallini, Bruno Samori

Label-free DNA detection plays a crucial role in developing point-of-care biochips. Capacitance detection is apromising technology for label-free detection. However, data published in literature often show evident time drift, large standard deviation,scatt ...

2010

Hydrous manganese oxide doped gel probe sampler for measuring in situ reductive dissolution rates. 1. Laboratory development

Janet Gordon Hering

Reductive dissolution of redox-sensitive minerals such as manganese (Mn) oxides in natural sediments is an important mechanism for trace element mobilization into groundwater. A gel probe sampler has been constructed to study in situ reductive dissolution ...

2010

Microfluidic assays for DNA manipulation based on a block copolymer immobilization strategy

Demetri Psaltis, Andreas Vasdekis

Methods to manipulate and visualize isolated DNA and oligonucleotide strands are important for investigation of their biophysics as well as their interactions with proteins. Herein, we report such a method by combining a block copolymer surface functionali ...

2010

Access to long-chain polyketides by double-elongation reactions

Christopher Flowers

Due to the spongistatins' fascinating and complex molecular architectures, and their important biological activities, these marine macrolides have been the subject of intensive efforts directed towards their total synthesis. As an attractive alternative to ...

EPFL2010

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