Concept
Central tolerance
Related publications (103)
DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells
Freddy Radtke, Ute Koch, Stéphanie Claudinot
T-cell development depends upon interactions between thymocytes and thymic epithelial cells (TECs). The engagement of delta-like 4 (DL4) on TECs by Notch1 expressed by blood-borne BM-derived precursors is essential for T-cell commitment in the adult thymus ...
Wiley-Blackwell2013An implantable biosensor array for personalized therapy applications
At present, most of the tests involved in personalized medicine are complex and must be conducted in specialized centers. The development of appropriate, fast and inexpensive diagnostic technologies can encourage medical personnel in performing preventive ...
EPFL2013Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells
The thymus is a primary lymphoid organ where bone marrow derived T-cell progenitors come in contact with a unique microenvironment able to sustain their maturation into functional T-cells. This fundamental immunological function of the thymus is supported ...
EPFL2012Interstitial Fluid And Lymph Formation And Transport: Physiological Regulation And Roles In Inflammation And Cancer
Wiig H, Swartz MA. Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer. Physiol Rev 92: 1005-1060, 2012; doi: 10.1152/physrev.00037.2011.-The interstitium describes the fluid, proteins, solute ...
2012VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics
Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Susan Thomas, Amine Issa, Vidya Raghavan
Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...
Elsevier2012Transcription factor ROR alpha is critical for nuocyte development
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...
2012Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage
Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier, Susan Thomas
Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...
Amer Assoc Immunologists2012KAP1 regulates gene networks controlling T-cell development and responsiveness
Didier Trono, Isabelle Barde, Nicola Harris, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Karolina Bojkowska
Chromatin remodeling at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by Kruppel-associated box (KRAB)-associated protein 1 (KAP1), the universal cofactor of KRAB-zinc finger proteins (ZFPs), ...
Federation Amer Soc Exp Biol2012CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes
One target of protective immunity against the Plasmodium liver stage in BALB/c mice is represented by the circumsporozoite protein (CSP), and mainly involves its recognition by IFN-γ producing specific CD8+T-cells. In a previous in vitro study we showed th ...
Public Library of Science2012