Concept

Central tolerance

Related publications (103)

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Stephane Kontos, Jeffrey Alan Hubbell, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells

Freddy Radtke, Ute Koch, Stéphanie Claudinot

T-cell development depends upon interactions between thymocytes and thymic epithelial cells (TECs). The engagement of delta-like 4 (DL4) on TECs by Notch1 expressed by blood-borne BM-derived precursors is essential for T-cell commitment in the adult thymus ...

Wiley-Blackwell2013

An implantable biosensor array for personalized therapy applications

Andrea Cavallini

At present, most of the tests involved in personalized medicine are complex and must be conducted in specialized centers. The development of appropriate, fast and inexpensive diagnostic technologies can encourage medical personnel in performing preventive ...

EPFL2013

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

Melissa Maggioni

The thymus is a primary lymphoid organ where bone marrow derived T-cell progenitors come in contact with a unique microenvironment able to sustain their maturation into functional T-cells. This fundamental immunological function of the thymus is supported ...

EPFL2012

Interstitial Fluid And Lymph Formation And Transport: Physiological Regulation And Roles In Inflammation And Cancer

Melody Swartz

Wiig H, Swartz MA. Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer. Physiol Rev 92: 1005-1060, 2012; doi: 10.1152/physrev.00037.2011.-The interstitium describes the fluid, proteins, solute ...

2012

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Susan Thomas, Amine Issa, Vidya Raghavan

Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...

Elsevier2012

Transcription factor ROR alpha is critical for nuocyte development

Freddy Radtke, Ute Koch

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...

2012

Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage

Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier, Susan Thomas

Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...

Amer Assoc Immunologists2012

KAP1 regulates gene networks controlling T-cell development and responsiveness

Didier Trono, Isabelle Barde, Nicola Harris, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Karolina Bojkowska

Chromatin remodeling at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by Kruppel-associated box (KRAB)-associated protein 1 (KAP1), the universal cofactor of KRAB-zinc finger proteins (ZFPs), ...

Federation Amer Soc Exp Biol2012

CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes

One target of protective immunity against the Plasmodium liver stage in BALB/c mice is represented by the circumsporozoite protein (CSP), and mainly involves its recognition by IFN-γ producing specific CD8+T-cells. In a previous in vitro study we showed th ...

Public Library of Science2012

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