Concept

Central tolerance

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Central tolerance

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Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies

Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms

Selective Requirement for c-Myc at an Early Stage of V alpha 14i NKT Cell Development

The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development

Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair