A bitters (plural also bitters) is traditionally an alcoholic preparation flavored with botanical matter for a bitter or bittersweet flavor. Originally, numerous longstanding brands of bitters were developed as patent medicines, but now are sold as digestifs, sometimes with herbal properties, and as cocktail flavorings. Since cocktails often contain sour and sweet flavors, bitters are used to engage another primary taste and thereby balance out the drink and make it more complex, giving it a more complete flavor profile. The botanical ingredients used historically in preparing bitters have consisted of aromatic herbs, bark, roots, and/or fruit for their flavor and medicinal properties. Some of the more common ingredients are cascarilla, cassia (Chinese cinnamon), gentian, orange peel, and cinchona bark. Most bitters contain both water and alcohol, the latter of which functions as a solvent for botanical extracts as well as a preservative. The alcoholic strength of bitters varies widely across brands and styles. Some modern bitters are made with vegetable glycerin instead, allowing those avoiding alcohol to enjoy them. The origins of bitters go back to the ancient Egyptians, who may have infused medicinal herbs in jars of wine. This practice was further developed during the Middle Ages, when the availability of distilled alcohol coincided with a renaissance in pharmacognosy, which made possible more-concentrated herbal bitters and tonic preparations. Many of the brands and styles of digestive bitters today reflect herbal stomachic and tonic preparations whose roots are claimed to be traceable back to Renaissance-era pharmacopoeia and traditions. By the nineteenth century, the British practice of adding herbal bitters (used as preventive medicines) to Canary wine had become immensely popular in the former American colonies. By 1806, American publications referenced the popularity of a new preparation, termed a cocktail, which was described as a combination of "a stimulating liquor, composed of spirits of any kind, sugar, water, and bitters.