Publications related to Clinical study design

Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects

Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...

Lippincott Williams & Wilkins2024

Beam Loss Simulations for the Proposed TATTOS Beamline at HIPA

Mike Seidel, Hui Zhang

IMPACT (Isotope and Muon Production with Advanced Cyclotron and Target Technologies) is a proposed initia- tive envisaged for the high-intensity proton accelerator fa- cility (HIPA) at the Paul Scherrer Institute (PSI). As part of IMPACT, a radioisotope ta ...

JACoW (Joint Accelerator Conferences Website)2024

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Antonia Neels, Marianne Liebi, Tiberiu Totu

Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...

Elsevier2024

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Classification of patients with cardiac amyloidosis using machine learning models on Italian electronic clinical health records

Silvestro Micera, Sara Mazzucato

Amyloidosis refers to a range of medical conditions in which misshapen proteins accumulate in various organs and tissues, forming insoluble fibrils. Cardiac amyloidosis is frequently linked to the buildup of misfolded transthyretin (TTR) or immunoglobulin ...

New York2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital

Corinne Scaletta, Philippe Abdel Sayed, Nathalie Hirt-Burri, Alexis Laurent, Vincent Gremeaux

Platelet-rich plasma (PRP) preparations have recently become widely available in sports medicine, facilitating their use in regenerative therapy for ligament and tendon affections. Quality-oriented regulatory constraints for PRP manufacturing and available ...

MDPI2023

A Unified Experiment Design Approach for Cyclic and Acyclic Causal Models

Negar Kiyavash, Ehsan Mokhtarian, Saber Salehkaleybar

We study experiment design for unique identification of the causal graph of a system where the graph may contain cycles. The presence of cycles in the structure introduces major challenges for experiment design as, unlike acyclic graphs, learning the skele ...

2022

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Clinical study design

Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects

Beam Loss Simulations for the Proposed TATTOS Beamline at HIPA

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Rapid low-cost hyperspectral imaging system for quantitative assessment of infantile hemangioma

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Classification of patients with cardiac amyloidosis using machine learning models on Italian electronic clinical health records

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital

A Unified Experiment Design Approach for Cyclic and Acyclic Causal Models

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Chat with Graph Search

Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects

Beam Loss Simulations for the Proposed TATTOS Beamline at HIPA

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Classification of patients with cardiac amyloidosis using machine learning models on Italian electronic clinical health records

Rapid low-cost hyperspectral imaging system for quantitative assessment of infantile hemangioma

A Unified Experiment Design Approach for Cyclic and Acyclic Causal Models

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital