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The preparation of O-hexofuranosides was accomplished from unprotected 1-thioimidoyl furanosides as donors. The present methodology was first used for the synthesis of octyl galactofuranoside and further extended to D-galactofuranose-containing disaccharid ...
Understanding the surface O-3 response over a "receptor" region to emission changes over a foreign "source" region is key to evaluating the potential gains from an international approach to abate ozone (O-3) pollution. We apply an ensemble of 21 global and ...
A recombinant avidin-producing Mut(+) Pichia pastoris strain was used as a model organism to study the influence of the methanol feeding strategy on the specific product productivity (q(p)) and protein glycosylation. Fed-batch cultivations performed at var ...
The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously ide ...
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...
American Society for Biochemistry and Molecular Biology2007
The present invention concerns an intermediate of the following formula (I) in which R1 and R2 represent independently of each other a C1-C12 alkyl group, a (C1-C12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C2-C12 ...
Chiral BINOL phosphorochloridites were esterified and amidated with enantiopure 6-hydroxytropinone [6-hydroxy-8-azabicyclo[3.2.1]octan-3-one] cyclic acetal to yield chiral bidentate and monodentate phosphite-phosphoramidite ligands for copper-catalyzed asy ...
The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C ...
The glycoprotein IgM is the major antibody produced in the primary immune response to antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a single J chain, which is absent in the hexamer. The mu (heavy) chain of IgM has ...
American Society for Biochemistry and Molecular Biology2005
The combined and ordered sequential action of glycosidases and glycosyltransferases in mammalian cell compartments leads to the addition of defined glycans to proteins and lipids. Altered glycosylation patterns, neoexpression, underexpression or overexpres ...
