The Takeda Pharmaceutical Company Limited takeꜜda jakɯçiŋ koꜜːɡjoː is a Japanese multinational pharmaceutical company, with partial American and British roots. It is the largest pharmaceutical company in Asia and one of the top 20 largest pharmaceutical companies in the world by revenue (top 10 following its merger with Shire). The company has over 49,578 employees worldwide and achieved US19.299billioninrevenueduringthe2018fiscalyear.Thecompanyisfocusedononcology,rarediseases,neuroscience,gastroenterology,plasma−derivedtherapiesandvaccines.ItsheadquartersislocatedinChuo−ku,Osaka,andithasanofficeinNihonbashi,Chuo,Tokyo.InJanuary2012,FortuneMagazinerankedtheTakedaOncologyCompanyasoneofthe100bestcompaniestoworkforintheUnitedStates.Asof2015,ChristopheWeberwasappointedastheCEOandpresidentofTakeda.TakedaPharmaceuticalswasfoundedin1781,andwasincorporatedonJanuary29,1925.Oneofthefirm′smainstaydrugsisActos(pioglitazone),acompoundinthethiazolidinedioneclassofdrugsusedinthetreatmentoftype2diabetes.Itwaslaunchedin1999.InFebruary2005,TakedaacquiredSanDiego,California,basedSyrrx,acompanyspecializinginhigh−throughputX−raycrystallography,forUS270 million.
In February 2008, Takeda acquired the Japanese operations of Amgen and rights to a dozen of the California biotechnology company's pipeline candidates for the Japanese market. In April, Takeda acquired Millennium Pharmaceuticals of Cambridge, Massachusetts, a company specializing in cancer drug research, for US$8.8 billion. The acquisition brought in Velcade, a drug indicated for hematological malignancies, as well as a portfolio of pipeline candidates in the oncology, inflammation, and cardiovascular therapeutic areas. Millennium now operates as an independent subsidiary. In May, the company licensed non-exclusively the RNAi technology platform developed by Alnylam Pharmaceuticals, creating a potentially long-term partnership between the companies.
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