Concept

Sedative

Related publications (6)

Multivariate patterns of disrupted sleep longitudinally predict affective vulnerability to psychosis in 22q11.2 Deletion Syndrome

22q11.2 deletion syndrome (22q11DS) contributes dramatically to increased genetic risk for psychopathology, and in particular schizophrenia. Sleep disorders, including obstructive sleep apnea (OSA), are also highly prevalent, making 22q11DS a unique model ...

ELSEVIER IRELAND LTD2023

A Wearable Device For Physical and Emotional Health Monitoring

David Atienza Alonso, Francisco Javier Rincon Vallejos, Srinivasan Murali

Personal health monitoring systems are emerging as promising solutions to develop ultra-small, portable devices that can continuously monitor and process several vital body parameters. In this work, we present a wearable device for physical and emotional h ...

2015

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders

Damien Lapray

Insomnia is a serious medical and social problem, its prevalence in the general population ranges from 9 to 35% depending on the country and assessment method. Often, patients are subject to inappropriate and therefore dangerous pharmacotherapies that incl ...

Cambridge Univ Press2014

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Pénélope Andreux, Richardus Houtkooper, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

Patrick Fraering

A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relativ ...

2012

Forecasting respiratory rate in sedated patients with partial least squares regression

Jérémie Guignard

Remifentanil, like the other sedative drugs used to achieve conscious sedation, has an impact on the efficiency of patient ventilation. Since the quality of breathing has an indirect effect on blood O2 and CO2 concentrations, keeping patients' blood homeos ...

2009

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