Concept

Structural genomics

Related publications (230)

Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and Carboetherification

Vicinal amino alcohols are important structural motifs of bioactive compounds. Reported herein is an efficient method for their synthesis based on the palladium-catalyzed oxy-alkynylation, oxy-arylation, or oxy-vinylation of allylic amines. High regio- and ...

Wiley-Blackwell2015

Complete genome sequences of T5-related Escherichia coli bacteriophages DT57C and DT571/2 isolated from horse feces

Ricardo Cesar Guerrero Ferreira, Nikolai Prokhorov

We report the complete genome sequencing of two Escherichia coli T5-related bacteriophages, DT57C and DT571/2, isolated from the same specimen of horse feces. These two isolates share 96 % nucleotide sequence identity and can thus be considered representat ...

Springer Wien2015

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

Matteo Dal Peraro, Andrea Cavalli, Giulia Palermo

Two-metal-ion-dependent nucleases cleave the phosphodiester bonds of nucleic acids via the two-metal-ion (2M) mechanism. Several high-resolution X-ray structures portraying the two-metal-aided catalytic site, together with mutagenesis and kinetics studies, ...

Amer Chemical Soc2015

Synthesis, structural determination, theoretical studies and catalytic activity of Mn(II) complex of N-isonicotinyl phosphoric triamide ligand

Kurt Schenk, Farzaneh Fadaei Tirani

synthesized and characterized by H-1, C-13, P-31 NMR and IR spectroscopies. The reaction of MnCl2 center dot 4H(2)O with L led to the formation of a new 3D system {MnL2Cl2}(n)center dot 34CH(3)OH (C-1). X-ray crystallographic data revealed that the ligand ...

Elsevier Science Sa2015

Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain

Nicolas Jean Philippe Guex, Pascal Escher

NR2E3 encodes the photoreceptor-specific nuclear hormone receptor that acts as a repressor of cone-specific gene expression in rod photoreceptors, and as an activator of several rod-specific genes. Recessive variants located in the ligand-binding domain (L ...

Wiley-Blackwell2015

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Vogel, Horst Pick, Shuguang Yuan, Luc Veya, Olivia Baud

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

Defining a braking probability to estimate extreme braking forces on road bridges

Katrin Beyer, André-Gilles Dumont, Marc-Antoine Fénart, Glauco Feltrin

A probabilistic approach is necessary to estimate the magnitude of the braking force that compares in terms of return period with the vertical traffic loads present in bridge design codes. A data set from a Danish Field Operational Test served as support t ...

2015

Array-based sensing of purine derivatives with fluorescent dyes

Kay Severin, Ziya Köstereli

Natural and synthetic purine derivatives such as caffeine, theophylline, 6-mercaptopurine and 8-chlorotheophylline are important drugs. Due to the structural similarity of these compounds, it is intrinsically difficult to prepare chemosensors for their sel ...

Royal Soc Chemistry2015

Energy-Proportional Single-Carrier Frequency Domain Equalization for mmWave Wireless Communication

Andreas Peter Burg, Nicholas Alexander Preyss, Sara Rodriguez Egea

mmWave wireless communication is proposed for high-throughput and high-density applications. Due to the large channel bandwidth, mmWave systems face a large variation in the observed delay spread. Many proposed single-carrier (SC) mmWave systems rely on cy ...

2015

HCV E2 core structures and mAbs: something is still missing

Matteo Dal Peraro, Matteo Castelli

The lack of structural information on hepatitis C virus (HCV) surface proteins has so far hampered the development of effective vaccines. Recently, two crystallographic structures have described the core portion (E2c) of E2 surface glycoprotein, the primar ...

Elsevier Sci Ltd2014

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