Publications related to Structural genomics

Projection Structure of the Secondary Citrate/Sodium Symporter CitS at 6 angstrom Resolution by Electron Crystallography

CitS from Klebsiella pneumoniae acts as a secondary symporter of citrate and sodium ions across the inner membrane of the host. The protein is the best characterized member of the 2-hydroxycarboxylate transporter family, while no experimental structural in ...

Elsevier BV2012

Design and implementation of a flexible beamline for fs electron diffraction experiments

Fabrizio Carbone, Giulia Fulvia Mancini, Saverio Pagano

Ultrafast Electron Diffraction (UED) has been widely used to investigate the structural dynamics of molecules and materials. Femtosecond (fs) electron bunches are used to obtain diffraction images of a specimen upon photo-excitation by a temporally delayed ...

Elsevier2012

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

Ursula Röthlisberger, Chandan Patel

DNA damages induced by oxidative intrastrand cross-links have been the subject of intense research during the past decade. Yet, the currently available experimental protocols used to isolate such lesions only allow to get structural information about linke ...

2012

On the active site of mononuclear B1 metallo beta-lactamases: a computational study

Matteo Dal Peraro, Paolo Carloni

Metallo-beta-lactamases (M beta Ls) are Zn(II)-based bacterial enzymes that hydrolyze beta-lactam antibiotics, hampering their beneficial effects. In the most relevant subclass (B1), X-ray crystallography studies on the enzyme from point to either two zinc ...

2012

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

David Lyndon Emsley

We introduce a new approach to improve structural and dynamical determination of large metalloproteins using solid-state nuclear magnetic resonance (NMR) with H-1 detection under ultrafast magic angle spinning (MAS). The approach is based on the rapid and ...

NATL ACAD SCIENCES2012

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Alessandra Griffa, Aristotelis Agianniotis, Jelle Tymen Christiaan Schrauwen

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Capturing and Animating the Morphogenesis of Polygonal Tree Models

Boris Neubert

Given a static tree model we present a method to compute developmental stages that approximate the tree's natural growth. The tree model is analyzed and a graph-based description its skeleton is determined. Based on structural similarity, branches are adde ...

Assoc Computing Machinery2012

Global Solutions to a Non-Local Diffusion Equation with Quadratic Non-Linearity

Joachim Krieger

In this paper we prove the global in time well-posedness of the following non-local diffusion equation with

\alpha\, \varepsilon [0, 2/3)

:

\partial_tu=\{(-\Delta)^{-1}u\}\Delta u+\alpha u^2, \,\, u(t=0)=u_0

. The initial condition

u_0

is positive, rad ...

2012

Scanning tunneling microscopy at multiple voltage biases of stable “ring-like” Ag clusters on Si(111)–(7×7)

Corsin Battaglia, Laure-Emmanuelle Perret Aebi, Philipp Aebi

Since more than twenty years it is known that deposition of Ag onto Si(111)–(7×7) leads under certain conditions to the formation of so-called “ring-like” clusters, that are particularly stable among small clusters. In order to resolve their still unknown ...

Elsevier2012

Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide

Julien Maillard

The twin-arginine translocation (Tat) pathway is a protein targeting system present in many prokaryotes. The physiological role of the Tat pathway is the transmembrane translocation of fully-folded proteins, which are targeted by N-terminal signal peptides ...

Wiley-Blackwell2012

Structural genomics

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Projection Structure of the Secondary Citrate/Sodium Symporter CitS at 6 angstrom Resolution by Electron Crystallography

Design and implementation of a flexible beamline for fs electron diffraction experiments

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

On the active site of mononuclear B1 metallo beta-lactamases: a computational study

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Capturing and Animating the Morphogenesis of Polygonal Tree Models

Global Solutions to a Non-Local Diffusion Equation with Quadratic Non-Linearity

Scanning tunneling microscopy at multiple voltage biases of stable “ring-like” Ag clusters on Si(111)–(7×7)

Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide

Projection Structure of the Secondary Citrate/Sodium Symporter CitS at 6 angstrom Resolution by Electron Crystallography

Design and implementation of a flexible beamline for fs electron diffraction experiments

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

On the active site of mononuclear B1 metallo beta-lactamases: a computational study

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Global Solutions to a Non-Local Diffusion Equation with Quadratic Non-Linearity

Scanning tunneling microscopy at multiple voltage biases of stable “ring-like” Ag clusters on Si(111)–(7×7)

Capturing and Animating the Morphogenesis of Polygonal Tree Models