Concept
Cardiac skeleton
Related publications (27)
Efficient approximation of cardiac mechanics through reduced-order modeling with deep learning-based operator approximation
Alfio Quarteroni, Andrea Manzoni
Reducing the computational time required by high-fidelity, full-order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. Indeed, while FOMs, such as th ...
Hoboken2023Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal Zn(II), resultin ...
FUTURE SCI LTD2020Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities
Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...
EPFL2020Complex blood flow patterns in an idealized left ventricle: A numerical study
Alfio Quarteroni, Anna Tagliabue
In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...
Amer Inst Physics2017MATHICSE Technical Report : A complex blood flow patterns in an idealized left ventricle: a numerical study
Alfio Quarteroni, Luca Dede', Anna Tagliabue
In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...
MATHICSE2017Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2
Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 ...
Springer2016Study of the impact of electrical heterogeneities in the right and left atrium on atrial fibrillation perpetuation
Jean-Marc Vesin, Adrian Luca, Vincent Jacquemet
Introduction: Electrical heterogeneity in the atria has been consistently linked with the initiation and perpetuation of atrial fibrillation (AF). The present model-based study investigated the contribution of action potential duration (APD) heterogeneitie ...
2016Study of the impact of electrical heterogeneities in the right and left atrium on atrial fibrillation perpetuation
Jean-Marc Vesin, Adrian Luca, Vincent Jacquemet
Introduction: Electrical heterogeneity in the atria has been consistently linked with the initiation and perpetuation of atrial fibrillation (AF). The present model-based study investigated the contribution of action potential duration (APD) heterogeneitie ...
Oxford Univ Press2016Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws
Alfio Quarteroni, Simone Deparis, Luca Dede', Paolo Tricerri, Adélia Sequeira
This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...
Springer Verlag2015Improved temporal resolution for functional studies with reduced number of segments with three-dimensional echo planar imaging
Rolf Gruetter, Tobias Kober, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, Mayur Narsude
PURPOSE: To introduce a new k-space traversal strategy for segmented three-dimensional echo planar imaging (3D EPI) that encodes two partitions per radiofrequency excitation, effectively reducing the number excitations used to acquire a 3D EPI dataset by h ...
Wiley-Blackwell2014