Concept

Complementarity (molecular biology)

Related publications (76)

Living in interesting times

Interactions of transmembrane (TM) helices play a key role in many cell processes. The configuration and cross angle these helices adopt are traditionally attributed to specific residue interactions. We present a different approach, in which specific resid ...

EPFL2013

A Genetic Basis for Altered Sexual Behavior in Mutant Female Mice

Denis Duboule, Jozsef Zakany

Although neural substrates of mammalian female mating behavior have been described [1, 2], the association between complex courtship activity and specific underlying mechanisms remains elusive [3]. We have isolated a mouse line that unexpectedly shows alte ...

Elsevier2012

Unique Cell-Type-Specific Distributions and Functions of Brain MicroRNAs

Ana Jovicic

MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. The first miRNA was discovered less than 20 years ago in the context of studying Caenorabditis elegans development. The discovery of the second miR ...

EPFL2011

Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A

Ronan Euzen, Jean-Louis Reymond

We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A ...

Elsevier2011

Cooperative kinking at distant sites in mechanically stressed DNA

Davide Demurtas, Julien Dorier, Andrzej Stasiak, Guillaume Witz

In cells, DNA is routinely subjected to significant levels of bending and twisting. In some cases, such as under physiological levels of supercoiling, DNA can be so highly strained, that it transitions into non-canonical structural conformations that are c ...

Oxford University Press2011

Identification of microRNA-regulated gene networks by expression analysis of target genes

Giovanni D'Angelo

MicroRNAs (miRNAs) and transcription factors control eukaryotic cell proliferation, differentiation, and metabolism through their specific gene regulatory networks. However, differently from transcription factors, our understanding of the processes regulat ...

2010

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Ralf Schneggenburger, Olexiy Kochubey, Heather Mary Elizabeth Murray, Heike Runne, Yunyun Han, Le Xiao

The large glutamatergic calyx of Held synapse in the auditory brainstem has become a powerful model for studying transmitter release mechanisms, but the molecular bases of presynaptic function at this synapse are not well known. Here, we have used single-c ...

2010

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara

Gold(I) complexes bearing water-sol. phosphine ligands, including 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and sodium triphenylphosphine trisulfonate (TPPTS), in combination with thionate liga ...

Wiley-Blackwell2010

Dissecting regulatory networks in host-pathogen interaction using chIP-on-chip technology

Stewart Cole, Claudia Sala

Understanding host-microbe interactions has been greatly enhanced by our broadening knowledge of the regulatory mechanisms at the heart of pathogenesis. The "transcriptomics" approach of measuring global gene expression has identified genes involved in bac ...

2009

Complex networks

Cécile Caretta Cartozo

The last decade has witnessed a fundamental change in the role of network theory. Side by side with the increasing relevance of interdisciplinarity, this ensemble of mathematical tools and methods has known such a success and such a wide range of different ...

EPFL2009

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