Concept
Alpha-1 antitrypsin deficiency
Related publications (29)
Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme
Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...
Frontiers Media Sa2024Nitrogen Fixation and Hydrogen Evolution by Sterically Encumbered Mo-Nitrogenase
The substrate-reducing proteins of all nitrogenases (MoFe, VFe, and FeFe) are organized as alpha 2ss2(gamma 2) multimers with two functional halves. While their dimeric organization could afford improved structural stability of nitrogenases in vivo, previo ...
AMER CHEMICAL SOC2023Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin
Florian Maria Wurm, Divor Kiseljak
For the treatment of severe COVID-19, supplementation with human plasma-purified alpha-1 antitrypsin (AAT) to patients is currently considered. AAT inhibits host proteases that facilitate viral entry and possesses broad anti-inflammatory and immunomodulato ...
MDPI2021Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin
Polymorphonuclear neutrophils contain at least four serine endopeptidases, namely neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and NSP4, which contribute to the regulation of infection and of inflammatory processes. In physiological co ...
2020Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice
Hongxia Lei, Ana Francisca Leal Silva Soares
This study demonstrates the suitability of magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) for the imaging of congenital portosystemic shunts (PSS) in mice, a vascular abnormality in which mesenteric blood bypasses the liver and i ...
2018