Concept

Social stigma of obesity

Related publications (33)

A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal

Martinus Gijs, Guy Vergères, Flurina Schwander, Reto Portmann

A dose-response strategy may not only allow investigation of the impact of foods and nutrients on human health but may also reveal differences in the response of individuals to food ingestion based on their metabolic health status. In a randomized crossove ...

Amer Soc Nutrition-Asn2014

Effects of Age, Sex and Treatment on Weight Loss Dynamics in Overweight People

David Atienza Alonso, Emiliano Luis Rincon Vallejos

The objective of this work is the evaluation of how sex, age and the kind of followed treatment affect weight loss, as well as the development of an explanation to assess the evolution of weight loss dynamics in overweight men and women. The methods use in ...

Canadian Science Publishing, Nrc Research Press2013

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

Carine Delattre-Gubelmann

Excess fat mass in obese individuals, which is characterized by an increase of white adipocyte cell size and number, significantly raises the risk of developing metabolic syndrome symptoms as well as cancer. A detailed understanding of the transcriptional ...

EPFL2013

Classification of stance and swing gait states during treadmill walking from non-invasive scalp electroencephalographic (EEG) signals

Pierre-André Farine, Sara Grassi Pauletti, Fernando San Martin Jorquera

In Contreras-Vidal and colleagues have shown the feasibility of inferring the linear and angular kinematics of treadmill walking from scalp EEG. Here, we apply a discrete approach to the same problem of decoding the human gait. By reducing the gait process ...

Springer2012

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis

Eija Riitta Pirinen

The mitochondrial biogenesis and energy expenditure regulator, PGC-1 alpha, has been previously reported to be induced in the white adipose tissue (WAT) and liver of mice overexpressing spermidine/spermine N (1)-acetyltransferase (SSAT). The activation of ...

2012

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Johan Auwerx

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...

Public Library of Science2010

pRb, a switch between bone and brown fat

Johan Auwerx, Pablo Jose Fernandez Marcos

Calo et al. (2010) recently reported that the absence of the transcriptional regulator pRb enhances differentiation of mesenchymal precursors toward the brown adipocyte lineage in detriment of osteoblast and white fat populations. These findings may have t ...

Elsevier2010

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population

Johan Auwerx

Peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a role in adipocyte differentiation and insulin sensitization. We identified and characterized a new C/T substitution at position -689 (-689C>T) in the P2 promoter of PPARgamma in a putativ ...

2005

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Johan Auwerx

Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is critical in the development of therapeutic strategies for the treatment of diabetes. Recently, mice deficient for S6 Kinase 1 (S6K1), an effector of the mammalian ta ...

2004

Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men

Johan Auwerx

AIMS/HYPOTHESIS: The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) w ...

1999

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