Publications related to Mammary gland

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Denis Duboule, Jozsef Zakany, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Virginie Marcet

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...

National Academy of Sciences2016

Endocrine hormones and local signals during the development of the mouse mammary gland

Cathrin Brisken, Dalya Ataca

Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...

Wiley-Blackwell2015

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Cathrin Brisken, Kathryn Hess Bellwald

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Cathrin Brisken, Jacques Rougemont, Ayyakkannu Ayyanan, Marian Caikovski, Renuga Devi Rajaram, Duje Buric

Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...

Wiley-Blackwell2015

An Ex vivo Model to Study Hormone Action in the Human Breast

Cathrin Brisken, Georgios Sflomos

The study of hormone action in the human breast has been hampered by lack of adequate model systems. Upon in vitro culture, primary mammary epithelial cells tend to lose hormone receptor expression. Widely used hormone receptor positive breast cancer cell ...

Journal of Visualized Experiments2015

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Daniel Constam, Jacques Rougemont, Anne Grapin-Botton, Joan Goulley, Laurence Anne E Lemaire, Yung Hae Kim

In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads to left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed i ...

Company Of Biologists Ltd2015

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Cathrin Brisken

Abstract | Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxife ...

Nature Publishing Group2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Tamara Tanos, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

ER and PR signaling nodes during mammary gland development

Cathrin Brisken, Tamara Tanos, Lucia Jimenez Rojo

The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling ste ...

BioMed Central2012

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Mammary gland

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Endocrine hormones and local signals during the development of the mouse mammary gland

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Mechanisms underlying cell-fate determination in the mammary gland development

An Ex vivo Model to Study Hormone Action in the Human Breast

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

ER and PR signaling nodes during mammary gland development

Graph Chatbot

Chat with Graph Search

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Mechanisms underlying cell-fate determination in the mammary gland development

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Endocrine hormones and local signals during the development of the mouse mammary gland

An Ex vivo Model to Study Hormone Action in the Human Breast

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

ER and PR signaling nodes during mammary gland development

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast