Concept

Moss bioreactor

Related publications (17)

Co-culture of microalgae-activated sludge for wastewater treatment and biomass production: Exploring their role under different inoculation ratios

In this study, mixed culture (microalgae:activated sludge) of a photobioreactor (PBR) were investigated at different inoculation ratios (1:0, 9:1, 3:1, 1:1, 0:1 wt/wt). This work was not only to determine the optimal ratio for pollutant remediation and bio ...

2020

A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Marc Moniatte, Dominique Terry Monteil Jr, Valentin Juvet

Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer ra ...

American Chemical Society2016

Constant-yield control of continuous bioreactors

Georgios Savoglidis

The process of anaerobic digestion is a common application in the treatment of industrial and communal wastewater treatment plants. The biochemical reactions taking place inside the fermenter can be described by a system of first order differential equatio ...

Elsevier Science Sa2013

Optimization of a dynamic compression bioreactor to evaluate mechano-transduction in 3D hydrogel-encapsulated cartilage progenitor cells.

Salim Elias Darwiche

Mechanical stimuli have fundamental repercussions on a cell’s phenotype and response in vivo. Studying these effects in a controlled in vitro bioreactor system allows bioengineers to hone in on the regenerative potential of therapeutic cells to better desi ...

2012

Innovative, Non-stirred Bioreactors in Scales from Milliliters up to 1000 Liters for Suspension Cultures of Cells using Disposable Bags and Containers – A Swiss Contribution

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Mathieu Benjamin Stettler, Stéphanie Tissot, Xiaowei Zhang, Gilles Broccard

Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave' , or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for ...

Schweizerische Chemische Gesellschaft2010

Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors

Christos Comninellis, Florian Maria Wurm, Mohamed Farhat, David Hacker, Stéphanie Tissot

Efficient mixing in bioreactors is essential in order to avoid concentration gradients which can be harmful for mammalian cells. To study mixing and its scalability in orbitally shaken cylindrical bioreactors, we measured mixing times in containers with no ...

Elsevier2010

Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

Alfio Quarteroni, Florian Maria Wurm, David Hacker, Mathieu Benjamin Stettler, Xi Zhang

Driven by the commercial success of recombinant biopharmaceuticals, there is an increasing demand for novel mammalian cell culture bioreactor systems for the rapid production of biologicals that require mammalian protein processing. Recently, orbitally sha ...

2009

Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air

Florian Maria Wurm, David Hacker, Xiuwei Zhang, Mathieu Benjamin Stettler

A new scalable reactor was developed by applying a novel mixing principle that allows the large-scale cultivation of mammalian cells simply with surface aeration using air owing to increased liquid–gas transfer compared to standard stirred-tank bioreactors ...

Elsevier2008

Metabolic engineering under uncertainty. I: Framework development

Vassily Hatzimanikatis

Std. bioprocess conditions have been widely applied for the microbial conversion of raw material to essential industrial products. Successful metabolic engineering (ME) strategies require a comprehensive framework to manage the complexity embedded in cellu ...

2006

Application of bench-scale biocalorimetry to photoautotrophic cultures

Urs von Stockar

Bench-scale biocalorimetry (>=1 L) allows for the detn. of the metabolic heat flow during bioprocesses under complete control of all process conditions for extended periods of time. It can be combined with a no. of online and off-line measurement technique ...

2005

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