Concept

Microfilament

Related publications (117)

Numerically bridging lamellipodial and filopodial activity during cell spreading reveals a potentially novel trigger of focal adhesion maturation

We present a novel approach to modeling cell spreading, and use it to reveal a potentially central mechanism regulating focal adhesion maturation in various cell phenotypes. Actin bundles that span neighboring focal complexes at the lamellipodium-lamellum ...

2012

Cell-type-specific 2 adrenergic receptor clusters identified using photo-activated localization microscopy are not lipid raft related, but depend on actin cytoskeleton integrity

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli

Recent developments in the field of optical super-resolution techniques allow both a 10-fold increase in resolution as well as an increased ability to quantify the number of labeled molecules visualized in the fluorescence measurement. By using photoactiva ...

2012

Mechanisms of LRRK2-Mediated Neurodegeneration

Elpida Tsika, Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common cause of familial Parkinson's disease (PD), whereas common variation at the LRRK2 locus is associated with an increased risk of idiopathic PD. Considerable progress has be ...

Current Science Inc., Springer2012

Statistical analysis of the current-sharing temperature evolution in Nb3Sn cable-in-conduit-conductors for ITER

Pierluigi Bruzzone, Davide Uglietti, Boris Stepanov, Rainer Wesche

During the test of ITER conductors at nominal conditions, a degradation of the current sharing temperature has been observed after electromagnetic cyclic loading. Rather than focusing on the microscopic phenomena at the origin of the degradation, the degra ...

IEEE-Inst Electrical Electronics Engineers Inc2012

Palmitoylated calnexin is a key component of the ribosome-translocon complex

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Laurence Gouzi Abrami, Béatrice Kunz, Thomas Lemmin, Sanja Blaskovic

A third of the human genome encodes N-glycosylated proteins. These are co-translationally translocated into the lumen/membrane of the endoplasmic reticulum (ER) where they fold and assemble before they are transported to their final destination. Here, we s ...

2012

Stiffness tomography exploration of living and fixed macrophages

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Charles Roduit, Bhaskar Saha, Andrea Volterra

Stiffness tomography is a new atomic force microscopy imaging technique that allows highlighting structures located underneath the surface of the sample. In this imaging mode, such structures are identified by investigating their mechanical properties. We ...

Wiley-Blackwell2012

A Role for Septins in the Interaction between the Listeria monocytogenes Invasion Protein InlB and the Met Receptor

Sandor Kasas, Charles Roduit

Septins are conserved GTPases that form filaments and are required for cell division. During interphase, septin filaments associate with cellular membrane and cytoskeleton networks, yet the functional significance of these associations have, to our knowled ...

Elsevier2011

A role for actin arcs in the leading-edge advance of migrating cells

Suliana Manley

Epithelial cell migration requires coordination of two actin modules at the leading edge: one in the lamellipodium and one in the lamella. How the two modules connect mechanistically to regulate directed edge motion is not understood. Using live-cell imagi ...

2011

Force Transmission in Migrating Cells

Maxime Fred Maurice Fournier

Ability to migrate is a fundamental property of all animal cells. Cell migration underlies such important physiological and pathological processes as embryonic development, immune response, tissue regeneration and cancer metastasis. As cell migration invol ...

EPFL2011

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions

Li Tang, Amaresh Mishra

Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and receptor dependent), ha ...

2011

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