Publications related to Glutathione reductase

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

2024

A locally activatable sensor for robust quantification of organellar glutathione

Pablo Rivera Fuentes, Sarah Emmert, Gianluca Quargnali

Glutathione (GSH) is the main determinant of intracellular redox potential and participates in multiple cellular signalling pathways. Achieving a detailed understanding of intracellular GSH homeostasis depends on the development of tools to map GSH compart ...

NATURE PORTFOLIO2023

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio ...

SWISS CHEMICAL SOC2022

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Pablo Rivera Fuentes, Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced and oxidized glutathione. In eukaryotic cells, this ratio is different ...

ROYAL SOC CHEMISTRY2021

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Maria del Carmen Sandi Perez, Sarah Catherine Sonnay, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Eva Ramos Fernandez, Laia Morato Fornaguera

The mammalian brain has high energy demands, which may become higher in response to environmental challenges such as psychogenic stress exposure. Therefore, efficient neutralization of reactive oxygen species that are produced as a by-product of ATP synthe ...

2020

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

Pablo Rivera Fuentes, Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is assocd. with cancer, metabolic and neurodegenerative diseases. Redox balance is largely regulated by the relative concns. of reduced and oxidized glutathione. In eukaryotes, this ratio ...

2019

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

Pablo Rivera Fuentes

Subcellular organelles maintain distinct redox environments to carry out their normal physiol. functions. Disruption of redox homeostasis, either in the oxidative or reductive direction, is linked to disease. We recently showed that trialkylphosphine-based ...

American Chemical Society2019

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Rolf Gruetter, Lijing Xin, Alessandra Griffa, Patric Hagmann, Kim Do, Emeline Mullier

Background: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, ...

Oxford University Press (OUP)2019

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Glutathione reductase

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

A locally activatable sensor for robust quantification of organellar glutathione

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

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Chat with Graph Search

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

A locally activatable sensor for robust quantification of organellar glutathione

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe