Concept
Lipid storage disorder
Related publications (20)
Metabolic dependencies of metastasis-initiating cells in female breast cancer
Albert Santamaria Martinez, Pierre Vincent Dessen, Angela Madurga Alonso, Candice Megan T Young, Laurent Nam Ky Beziaud
Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...
Berlin2023Post-translational regulation of neuronal differentiation
Glycosphingolipids (GSLs) are amphipathic lipid moieties that make up only 3% of the total lipid content of the cell and are almost exclusively expressed at the Plasma Membrane(PM). They are key drivers of signalling hotspots known as âlipid-raftsâ as ...
EPFL2021Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divi ...
NATURE PUBLISHING GROUP2020Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells[S]
Jonathan Paz Montoya, Marc Moniatte
In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also i ...
2019Predicting Partitioning and Diffusion Properties of Nonpolar Chemicals in Biotic Media and Passive Sampler Phases by GC x GC
Jeremy Samuel Arey, Deedar Nabi
The chemical parameters needed to explain and predict bioavailability, biodynamics, and baseline toxicity are not readily available for most nonpolar chemicals detected in the environment. Here, we demonstrate that comprehensive two-dimensional gas chromat ...
Amer Chemical Soc2017Storage method and apparatus for random access memory using codeword storage
A memory circuit, such as an embedded DRAM array, stores information as groups of bits or data using information coding in storage and retrieval data, instead of each bit being stored separately. Write data words can be mapped to storage format words that ...
2016Carbon Capture and Storage: introductory lecture
Carbon Capture and Storage ( CCS) is the only available technology that allows us to significantly reduce our CO2 emissions while keeping up with the ever-increasing global energy demand. Research in CCS focuses on reducing the costs of carbon capture and ...
Royal Soc Chemistry2016A High Current Pulse-Power Supply for Flash Lamps in PV-Panel Measurement-Facilities
In this paper, a high current pulse power supply for the feeding of a flash lamp has been developed, on the base of a multilevel converter with cascaded cells. The pulsed high power is provided by capacitive energy storage, directly connected to the cells ...
2010