Concept
Cachexia
Related publications (18)
Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models
Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Keno Strotjohann, Alessia De Masi
Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...
Wiley2024Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Johan Auwerx, Olivier Burri, Xiaoxu Li, Tanes Imamura de Lima, Giacomo Vincenzo Giorgio Von Alvensleben, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Amélia Lalou, Renata Mangione
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis ...
2023The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019