Concept
Keratinocyte
Related publications (54)
Mathematical modeling of the re-epithelialization of a 3 dimensional (3d) human skin equivalent
Re-epithelialization is the dominant mode of healing in partial thickness wounds. In order to develop better strategies to monitor such wound healing, 3D HSE models and mathematical models have long been utilized to improve our understanding of epidermis f ...
2009On the replication of adeno-associated virus in the presence or absence of viral helper functions
Adeno-associated virus (AAV) is a small non-enveloped virus and as a member of the parvovirus family, it contains a single stranded DNA genome. AAV's life cycle in vitro is strongly dependent not only on cellular factors but also on helper functions provid ...
EPFL2009Multiple roles of Notch signaling in the regulation of epidermal development
Recent studies have shown that Notch signaling plays an important role in epidermal development, but the underlying molecular mechanisms remain unclear. Here, by integrating loss- and gain-of-function studies of Notch receptors and Hes1, we describe molecu ...
2008Understanding engraftment of cultured epidermal stem cells
The epidermis and its appendages protect our body from environmental hazards. Cells generated in the basal layer continuously replace the terminally differentiated keratinocytes that are shed off the epidermal surface. Long-term renewal depends on specific ...
EPFL2008Fine modulation of stem cell niche through mTOR pathway : Effects of physical and molecular parameters regulating mTOR pathway on keratinocyte stem cells
Epidermis is the outermost layer of the skin and is in direct contact with the external environment, requiring keratinocyte stem cells to adapt constantly. Recently, our laboratory has put forward the role of mTOR in temperature-mediated keratinocyte stem ...
2008Low-frequency electromagnetic field effects on functional groups in human skin keratinocytes cells revealed by IR-SNOM
Giorgio Margaritondo, Dusan Vobornik
Human HaCaT cells, exposed for 24 h to a 1 mT (rms) 50 Hz sinusoidal magnetic field in a temperature-regulated solenoid, suffer detectable changes in their biochemical properties and shapes. By using infrared wavelength-selective scanning near-field optica ...
2008Stem cells of stratified epithelia
Squamous stratified epithelia tissues are self-renewing, which quality implies the existence of stem cells. In skin the presence of bona fide multipotent stem cells has been demonstrated by long-term, serial grafting assays. We isolated, cultivated and exp ...
EPFL2008Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Ilaria Malanchi, Deepika Kassen
Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular ...
2008Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum
PfPK7 is an orphan protein kinase of Plasmodium falciparum with maximal homology to MEK3/6 and to fungal protein kinase A proteins in its C-terminal and N-terminal regions, respectively. We showed previously that recombinant PfPK7 is active on various subs ...
American Society for Microbiology2008Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function
Johan Auwerx, Kristina Schoonjans
Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPARalpha) activation modulates LC function. Ou ...
2007