Concept

Allodynia

Related publications (12)

An insular cortex - lateral amygdala network in fear learning

Animals are capable of evaluating sensory cues for possible threats and adapting their behaviours accordingly. Fear learning is an evolutionarily conserved behaviour crucial for animal survival, during which sensory percepts with a negative reinforcing qua ...

EPFL2022

During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization

Anne-Christine Schmid

Background Mechanical hyperalgesia and allodynia incidence varies considerably amongst neuropathic pain patients. This study explored whether sensory or psychological factors associate with mechanical hyperalgesia and brush allodynia in a human experimenta ...

WILEY2021

Acetylated tubulin is essential for touch sensation in mice

Kai Johnsson, Luc Reymond, Antonino Asaro

At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influenc ...

Elife Sciences Publications Ltd2016

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Grégoire Courtine

Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into cli ...

Elsevier Science Bv2015

Size and Viewpoint of an Embodied Virtual Body Affect the Processing of Painful Stimuli

Olaf Blanke, Joan Llobera Mahy

Looking at one's own body might induce visual analgesia. However, the cognitive and physiological mechanisms underlying such visual analgesia are unknown. Because body and pain representations in the brain are multisensory, and have been reported to partia ...

Churchill Livingstone2015

Illusory self-identification with an avatar reduces arousal responses to painful stimuli

Olaf Blanke, Christian Pfeiffer

Looking at one's own body has been shown to induce analgesia. In the present work we investigated whether illusory self-identification with an avatar, as induced experimentally through visuo-tactile stimulation, modulates the response to painful stimuli. I ...

Elsevier2014

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Bernard Schneider, Ying Liu, Philippe Guillaume Coune

Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha S causes neurodegeneration is unresolved. Because cellular accumulation of ...

Society for Neuroscience2012

Establishment of polarized microglial cells derived from mouse embryonic stem cells

Céline Ruegsegger

Microglia are the resident immune cells of the central nervous system (CNS). Microglia undergo rapid activation in response to even minor pathological changes in the CNS. The activation state of microglia and tissue macrophages is characterized by two extr ...

2010

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21

Melody Swartz, Alice Anna Tomei, Iraklis Kourtis

Tumor manipulation of host immunity is important for tumor survival and invasion. Many cancers secrete CCL21, a chemoattractant for various leukocytes and lymphoid tissue inducer cells, which drive lymphoid neogenesis. CCL21 expression by melanoma tumors i ...

2010

Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

Patrick Aebischer, Christopher Towne

BACKGROUND: Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic strategy for the treatment of persistent pain disorders such as neuropathic pa ...

2009

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