Publications related to Hypersensitivity

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Kristen Lorentz

Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine or ...

2017

Electronic Dura Mater Meddling in the Central Nervous System

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch

IMPORTANCE A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. OBJECTIVE To assess the potential of a novel clas ...

Amer Medical Assoc2017

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Horst Vogel, Horst Pick

Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that a ...

Public Library of Science2016

Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

Anne-Laure Gassner

The ability of pharmacological agents to target both "classical" risk factors and inflammation may be key for successful outcomes in the prevention and treatment of atherogenesis. Among the promising drugs interfering with cholesterol metabolism, we invest ...

Elsevier Science Inc2015

Adverse tissue reaction to corrosion at the neck-stem junction after modular primary total hip arthroplasty

Stefano Mischler, Pierre Mettraux

Complications related to the neck-stem junction of modular stems used for total hip arthroplasty (THA) are generating increasing concern. A 74-year-old male had increasing pain and a cutaneous reaction around the scar 1 year after THA with a modular neck-s ...

Elsevier Masson2015

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Benjamin John Marsland, Alexandre de Titta, Marie Ballester, Laura Jeanbart

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice

Pedro Miguel Nunes Pereira de Almeida Reis, Andrea Pfeifer, Marija Vukicevic, Andreas Muhs, Valérie Gafner, Anna Lucia Buccarello

Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide ...

Amer Soc Hematology2013

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Stephane Kontos, Jeffrey Alan Hubbell, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Harm-Anton Klok, Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Zuzana Kadlecova

Lysine-based polycations are widely used as nonviral carriers for gene delivery. This manuscript reports the results of a comparative study on the in vitro cytotoxicity of a library of three structural polylysine variants, namely, linear polylysine (LPL), ...

Amer Chemical Soc2012

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Hypersensitivity

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

Electronic Dura Mater Meddling in the Central Nervous System

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

Adverse tissue reaction to corrosion at the neck-stem junction after modular primary total hip arthroplasty

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

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Chat with Graph Search

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

Electronic Dura Mater Meddling in the Central Nervous System

Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

Adverse tissue reaction to corrosion at the neck-stem junction after modular primary total hip arthroplasty

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Engineering antigens for in situ erythrocyte binding induces T-cell deletion