Concept
Filariasis
Related publications (16)
High-resolution imaging and analysis of the intestinal bacterial load of Caenorhabditis elegans during early adulthood
Martinus Gijs, Farzad Rezaeianaran
We study the presence within the worm Caenorhabditis elegans (C. elegans) of a fluorescent strain of the worm's bacterial food (Escherichia coli (E. coli) OP50) during early adulthood. Use of a microfluidic chip based on a thin glass coverslip substrate al ...
ROYAL SOC CHEMISTRY2023An In Vivo Microfluidic Study of Bacterial Load Dynamics and Absorption in the C. elegans Intestine
Martinus Gijs, Thomas Lehnert, Vittorio Viri, Maël Arveiler
Caenorhabditiselegans (C. elegans) has gained importance as a model for studying host-microbiota interactions and bacterial infections related to human pathogens. Assessing the fate of ingested bacteria in the worm's intestine is therefore of great interes ...
MDPI2021Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers
Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson
Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps
Arne Seitz, Romain Guiet, Nicola Harris, Beatrice Volpe, Tiffany Babette Angélique Bouchery, Kathleen Shah, Manuel Kulagin, Mati André Marie Moyat
Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infec ...
CELL PRESS2020Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae
Beatrice Volpe, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery, Kathleen Shah
Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...
WILEY2020Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model
Caenorhabditis elegans is a performant model system for studying human biological processes and diseases and for pre-clinical phenotyping screenings of compounds. Microfluidics has been instrumental in enabling C. elegans-based drug assays, facilitating th ...
EPFL2018The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology
Intestinal helminth infections are a global health problem affecting particularly people living in poor countries. Heavy worm burdens can lead to nutritional and cognitive deficiencies. Type-two immunity plays a crucial role in promoting tissue repair and ...
EPFL2017Long-term culture and high-resolution imaging of C. elegans using an automated microfluidic platform
Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Govindan Narayanan Krishnamani
The nematode Caernohabditis elegans is one of the most employed small model organisms in biology. Studies on transgenic animals often require the accurate observation of highly localized fluorescent signals inside the worms at high magnification, hence dem ...
2015Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead
The rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host–parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became ...
Wiley-Blackwell2014Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression
Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the tumor microenvironment and in the tumor-draining lymph node. The mechanism unde ...
Amer Assoc Cancer Research2014