Concept
Chromosome 3
Related publications (29)
Computational identification and experimental characterization of preferred downstream positions in human core promoters
Author summary Transcription of genes by the RNA polymerase II enzyme initiates at a genomic region termed the core promoter. The core promoter is a regulatory region that may contain diverse short DNA sequence motifs/elements that confer specific properti ...
PUBLIC LIBRARY SCIENCE2021Learning Intelligent Dialogs for Bounding Box Annotation
Ksenia Konyushkova, Vittorio Ferrari
We introduce Intelligent Annotation Dialogs for bounding box annotation. We train an agent to automatically choose a sequence of actions for a human annotator to produce a bounding box in a minimal amount of time. Specifically, we consider two actions: box ...
IEEE2018Highly Reduced Genome of the New Species Mycobacterium uberis, the Causative Agent of Nodular Thelitis and Tuberculoid Scrotitis in Livestock and a Close Relative of the Leprosy Bacilli
Stewart Cole, Andrej Benjak, Charlotte Avanzi
Nodular thelitis is a chronic enzootic infection affecting dairy cows and goats. The causative agent was recently shown to be related to the leprosy-causing bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In this study, the genome of this path ...
AMER SOC MICROBIOLOGY2018Identifying and targeting key cellular mechanisms for proliferation in Plasmodium parasites: a combined experimental and computational strategy
Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...
2017Identifying and targeting key cellular mechanisms for proliferation in Plasmodium parasites: a combined experimental and computational strategy
Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...
2017Toward the identification of cellular mechanisms behind the lethal phenotypes in Plasmodium berghei blood stages with PlasmoGEM and metabolic modeling
Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...
2017Toward the identification of cellular mechanisms behind the lethal phenotypes in malaria parasites blood stages with PlasmoGEM and metabolic modeling
Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...
2017Olfactory receptor pseudo-pseudogenes
Matteo Dal Peraro, Benoîte Bargeton
Pseudogenes are generally considered to be non-functional DNA sequences that arise through nonsense or frame-shift mutations of protein-coding genes(1). Although certain pseudogene-derived RNAs have regulatory roles(2), and some pseudogene fragments are tr ...
Nature Publishing Group2016The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome
Jacques Fellay, Amalio Telenti, Istvan Bartha, Nimisha Chaturvedi
Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...
Public Library Science2015A novel homozygous R764H mutation in crumbs homolog 1 causes autosomal recessive retinitis pigmentosa
Purpose: Retinitis pigmentosa (RP; MIM 268000) is a hereditary disease characterized by poor night vision and progressive loss of photoreceptors, eventually leading to blindness. This degenerative process primarily affects peripheral vision due to the loss ...
Molecular Vision2013