Concept

Chromosome 15

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Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development

The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-ca ...

1994

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

Freddy Radtke

Metallothioneins (MTs) are small cysteine-rich proteins that bind heavy metal ions such as zinc, cadmium and copper with high affinity, and have been functionally implicated in heavy metal detoxification and radical scavenging. Transcription of metallothio ...

1994

The potential of the vertebrate limb as a model system to study developmental mechanisms is particularly well illustrated by the analysis of the Hox gene network. These genes are involved in the establishment of patterns and encode positional information. ...

1993

Integration and stability of CHO amplicons containing plasmid sequences

Florian Maria Wurm

Fluorescence in situ hybridization (FISH, 15) and high density, non-selective long term perfusion culture were used to study aspects of genetic stability and productivity in recombinant CHO cells. We analysed the distribution and structure of recombinant a ...

1992

Poly(A) polymerase is essential for the maturation of messenger RNA, adding tracts of adenosine residues to the 3' end of precursor RNA generated by endonucleolytic cleavage. This mechanism of mRNA 3' processing seems to be similar in yeast and in higher e ...

1991

Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ h ...

1990

Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.

Stewart Cole

In Klebsiella pneumoniae 86-4, cefotaxime resistance was due to a transferable broad-spectrum beta-lactamase, SHV-3. The plasmid-borne gene encoding SHV-3 has been cloned, and the primary structure of the enzyme was deduced from its nucleotide sequence. SH ...

1989

Use of fluorescence in situ hybridization to detect and monitor transfected and amplified sequences in recombinant CHO cells

Florian Maria Wurm

Non-radioactive fluorescence in situ hybridization was used to detect transfected and amplified sequences in recombinant CHO cells. The cell lines used in this study are based on DHFR-deficient CHO-DUKX cells. The recombinant CHO cells contain and express, ...

1989

Human chromosome 20 has not been sufficiently mapped, as only four DNA probes detecting RFLPs and 18 genes have been assigned to this chromosome. Using a chromosome 20-specific library to isolate and characterize new low-copy DNA probes, we found a new pol ...

1989

Chromosome segregation at meiosis I in female T(2;4)1Go/+ mice: no evidence for a decreased crossover frequency with maternal age

Friedrich Beermann

The influence of age and hormones on chromosome segregation at meiosis I was studied in female mice heterozygous for the T(2;4)1Go translocation. Females of two age groups (18-22 and 40-56 weeks old) were stimulated for ovulation with different doses of go ...

1987