Concept
Cholinergic
Related publications (13)
Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova
The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...
FRONTIERS MEDIA SA2019Visual masking in Schizophrenia: an endophenotype and its neural correlates
Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod
Objective: In visual backward masking, a target is followed by a mask, which deteriorates performance on the target. Masking is a very sensitive endophenotype for schizophrenia. Patients and their siblings (to a lesser extent) show strong performance defic ...
2019Visual backward masking and the schizophrenia spectrum: EEG correlates
Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod
Schizophrenia is a heterogeneous disease strongly influenced by genetic factors. We have previously shown that visual backward masking (VBM) is a very sensitive endophenotype of schizophrenia (Chkonia et al., 2010). Importantly, not only patients but also ...
2017Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits
David Paul Roger Romascano, Reto Meuli, Alessandro Daducci, Cristina Granziera, Djalel Eddine Meskaldji, Guillaume Bonnier, Ruslan Aydarkhanov, François Lazeyras
Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brai ...
Wiley2017Endophenotypes of schizophrenia: electrophysiological correlates of schizotypy
Michael Herzog, Christine Mohr, Ophélie Gladys Favrod, Guillaume Sierro
Endophenotypes are of crucial interest for schizophrenia research linking genetic abnormalities to pathology. During the last NCCR period, we have characterized one endophenotype, based on visual backward masking (VBM) deficits, behaviourally, electrophysi ...
2015Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition
The basal forebrain (BF) houses major ascending projections to the entire neocortex that have long been implicated in arousal, learning, and attention. The disruption of the BF has been linked with major neurological disorders, such as coma and Alzheimer's ...
Soc Neuroscience2015Automated design of ligands to polypharmacological profiles
The clinical efficacy and safety of a drug is determined by its activity profile across many proteins in the proteome. However, designing drugs with a specific multi-target profile is both complex and difficult. Therefore methods to design drugs rationally ...
Nature Publishing Group2012Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times
Rolf Gruetter, Giulio Gambarota
Proton spectroscopy allows the simultaneous quantification of a high number of metabolite concentrations termed the neurochemical profile. The spin echo full intensity acquired localization (SPECIAL) scheme with an echo time of 2.7 ms was used at 9.4T for ...
Wiley-Blackwell2008