Concept

Medical genetics

Related publications (55)

Inference of genealogies with geolocalised genetic data

Natural populations present an abundant genetic variability. Like mutation or natural se- lection, dierent processes are at stake to generate this variability. Population genetics is a topic that emerged in the late 40's, thanks mainly to the biologists Fi ...

2017

MedCo: Enabling Privacy-Conscious Exploration of Distributed Clinical and Genomic Data

Jean-Pierre Hubaux, Bryan Alexander Ford, Juan Ramón Troncoso-Pastoriza, Jean Louis Raisaro, Joao André Gomes de Sá e Sousa, Mickaël Misbach, Olivier Michielin

Being able to share large amounts of sensitive clinical and genomic data across several institutions is crucial for precision medicine to scale up. Unfor- tunately, existing solutions only partially address this challenge and are still unable to provide th ...

2017

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Hilal Lashuel, Magdalena Zweckstetter, Michael Heinrich

α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of th ...

Oxford University Press2017

Open computational landscape genetics

Stéphane Joost, Estelle Rochat, Ivo Widmer

Geographical Information Systems (GIS) are considered to be applications-led technology. Consequently, geographic information scientists commonly find themselves as guest in host disciplines in order to best exploit spatial analysis tools and methods, appr ...

2016

[Mendelian randomisation - a genetic approach to an epidemiological method]

Mats Julius Stensrud

BACKGROUND Genetic information is becoming more easily available, and rapid progress is being made in developing methods of illuminating issues of interest. Mendelian randomisation makes it possible to study causes of disease using observational data. The ...

2016

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Jeffrey David Jensen, Anna Ferrer Admetlla

The joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. However, additional informat ...

Genetics Society America2016

Antiviral drug resistance as an adaptive process

Kristen Kay Irwin, Jeffrey David Jensen

Antiviral drug resistance is a matter of great clinical importance that, historically, has been investigated mostly from a virological perspective. Although the proximate mechanisms of resistance can be readily uncovered using these methods, larger evoluti ...

Oxford University Press2016

The Drosophila gut response to infection

Maroun Bou Sleiman

Genetic, physiological, and biochemical studies have successfully ascribed functions to genes in diverse processes. However, the majority of our knowledge in biology is qualitative in nature and is usually based on classical screens, where large effects on ...

EPFL2016

Corneal Dystrophies: Overview and Summary

In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...

Elsevier Academic Press Inc2015

The genetics of social hierarchies

Maria del Carmen Sandi Perez, Michael van der Kooij

The organization of individuals in social hierarchies is ubiquitous in social species. Although the evolution of dominance at the population level is constrained by its interactive character, selective breeding shows that dominance and subordination can be ...

2015

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