Concept

Cancer epigenetics

Related publications (209)

A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors

A major goal of systems biology is to predict the function of biological networks. Although network topologies have been successfully determined in many cases, the quantitative parameters governing these networks generally have not. Measuring affinities of ...

2007

Melanoma Recognition using Kernel Classifiers

Barbara Caputo, Tatiana Tommasi

Melanoma is the most deadly skin cancer. Early diagnosis is a current challenge for clinicians. Current algorithms for skin lesions classification focus mostly on segmentation and feature extraction. This paper instead puts the emphasis on the learning pro ...

IDIAP2006

From gut homeostasis to cancer

Freddy Radtke

The mammalian intestine has one of the highest turnover rates in the body. The intestinal epithelium is completely renewed in less than a week. It is divided into spatially distinct compartments in the form of finger-like projections and invaginations that ...

2006

Different modes of human papillomavirus DNA replication during maintenance

Peter Martin Beard

Human papillomavirus (HPV) begins its life cycle by infecting the basal cells of the epithelium. Within these proliferating cells, the viral genomes are replicated, maintained, and passed on to the daughter cells. Using HPV episome-containing cell lines th ...

2006

Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

Peter Martin Beard, Sandra Eloise Kjeldsen, Christelle Dubey

The target gene(s) required for Myc-mediated tumorigenesis are still elusive. Here we show that while endogenous c-Myc is surprisingly dispensable for skin homeostasis and TPA-induced hyperplasia, c-Myc-deficient epidermis is resistant to Ras-mediated DMBA ...

2006

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

Anne Grapin-Botton

Mutations and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown [1-4]. This article reports a comprehe ...

2005

Sir-mediated repression can occur independently of chromosomal and subnuclear contexts

Thierry Laroche

Epigenetic mechanisms silence the HM mating-type loci in budding yeast. These loci are tightly linked to telomeres, which are also repressed and held together in clusters at the nuclear periphery, much like mammalian heterochromatin. Yeast telomere anchori ...

2004

DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay

Kai Johnsson

The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT, alkyltransferase) is an important suicide enzyme involved in defense against O6-alkylating endogenous metabolites and environmental carcinogens. It also plays a pivotal role in primary an ...

2003

Notch1 can contribute to viral-induced transformation of primary human keratinocytes

Peter Martin Beard

The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform a normal cell to a cancerous one. Instead, additional ce ...

2003

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

Johan Auwerx

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...

2003

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