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Blue Brain Project

Related publications (231)

Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study

While chronic hypoglycaemia has been reported to increase unidirectional glucose transport across the blood-brain barrier (BBB) and to increase GLUT1 expression at the endothelium, the effect on steady-state brain d-glucose and brain glycogen content is cu ...

Wiley-Blackwell2006

Segmentation of Brain Structures in Presence of a Space-Occupying Lesion

Jean-Philippe Thiran, Meritxell Bach Cuadra, Olivier Cuisenaire

Brain deformations induced by space-occupying lesions may result in unpredictable position and shape of functionally important brain structures. The aim of this study is to propose a method for segmentation of brain structures by deformation of a segmented ...

2005

Subthreshold cross-correlations between cortical neurons: A reference model with static synapses

Wulfram Gerstner, Henry Markram, Gilad Silberberg

The structure of cross-correlations between subthreshold potentials of neocortical neurons was recently examined. Characteristic features included broad widths and significant peak advances. It was suggested that dynamic synapses shape these cross-correlat ...

Elsevier2005

Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval

Pierre Magistretti, Luc Pellerin

Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding of hippocampal function. Using the (14C)-2-deoxyglucose autoradiographic method, we have chara ...

2005

Synaptic plasticity at the cerebellum input stage: mechanisms and functional implications

The mf-GrC relay provides the case of a synapse at which elementary neurotransmission mechanisms are particularly well understood allowing a precise investigation of synaptic plasticity. An interesting consequence is that a presynaptic mechanism of LTP cou ...

2005

Dynamics of population rate codes in ensembles of neocortical neurons

Henry Markram, Gilad Silberberg, Matthias Bethge

Information processing in neocortex can be very fast, indicating that neuronal ensembles faithfully transmit rapidly changing signals to each other. Apart from signal-to-noise issues, population codes are fundamentally constrained by the neuronal dynamics. ...

2004

Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex

Henry Markram

The computational power of the neocortex arises from interactions of multiple neurons, which display a wide range of electrical properties. The gene expression profiles underlying this phenotypic diversity are unknown. To explore this relationship, we comb ...

Oxford University Press2004

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Henry Markram, Gilad Silberberg, Yi Wang

Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...

2004

Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T

Rolf Gruetter

An efficient shim system and an optimized localization sequence were used to measure in vivo 1H NMR spectra from cerebral cortex, hippocampus, striatum, and cerebellum of C57BL/6 mice at 9.4 T. The combination of automatic first- and second-order shimming ...

Wiley-Blackwell2004

Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo

Rolf Gruetter

The rate of (13)C-label incorporation into both aspartyl (NAA C3) and acetyl (NAA C6) groups of N-acetyl aspartate (NAA) was simultaneously measured in the rat brain in vivo for up to 19 h of [1-(13)C]glucose infusion (n = 8). Label incorporation was detec ...

Wiley-Blackwell2004

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