Concept

Nicotinamide adenine dinucleotide

Related publications (141)

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Carlos Canto Alvarez, Sofia Moco, Joanna Ratajczak, Miriam Valera Alberni

Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously show ...

2019

Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham ...

CELL PRESS2019

Involvement of respiratory complex I in organohalide respiration?

Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin

Abstract Background The NADH:ubiquinone oxidoreductase (Nuo) is an assembly of proteins also known as complex I. It is the entry point for highly energetic electrons in the classical aerobic respiration process as it couples the transfer of two electrons f ...

2019

From structure to application: studies on adenine-, pyrene- and lanthanide-based metal-organic frameworks

Andrzej Gladysiak

Metal-organic frameworks (MOFs) are coordination polymer materials in which inorganic metal ions or clusters are linked with multitopic organic ligands by means of coordination bonds. Their structural versatility allows for design of materials based on pre ...

EPFL2019

Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities

Patrick Descombes, Sylviane Métairon, Sonia Karaz, Sofia Moco, Tanja Sonntag, Lei Feng

The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. H ...

Springer2019

Évolution d'un sol tourbeux travaillé soumis à une inondation saisonnière contrôlée.

Dans le cadre du projet Escale Limicole, un sol tourbeux cultivé est soumis à une inondation saisonnière afin d’aménager un site d’escale pour les limicoles. Cependant, les effets de l’inondation sur la fertilité du sol ne sont pas connus. Le but de l’étud ...

2019

Enhancing bioelectricity generation in microbial fuel cells and biophotovoltaics using nanomaterials

Ardemis Anoush Boghossian, Melania Reggente, Mohammed Mouhib, Alice Judith Gillen, Alessandra Antonucci, Amirmostafa Amirjani

Microbial fuel cells and biophotovoltaics represent promising technologies for green bioelectricity generation. However, these devices suffer from low durability and efficiency that stem from their reliance on living organisms to act as catalysts. Such lim ...

2019

De novo NAD(+) synthesis enhances mitochondrial function and improves health

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Karim Laurent Gariani, Marika Olga Zietak

Nicotinamide adenine dinucleotide (NAD(+)) is a co-substrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organi ...

NATURE PUBLISHING GROUP2018

Semisynthetic Biosensors for the Quantification of Nicotinamide Adenine Dinucleotides in Live Cells

Olivier Vincent Sallin

Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are crucial redox cofactors regulating energy metabolism, reductive biosynthesis and the antioxidant defense system. Besides their role as redox cofactors, NAD(P ...

EPFL2018

Identifying the role of complex I in organohalide respiration of Firmicutes

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin

Organohalide-respiring bacteria (OHRB) are capable to link energy conservation with the use of organohalide compounds as terminal electron acceptors. While obligate OHRB relies only on this process for growing, facultative OHRB are able to use alternative ...

2018

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