Concept
Alu element
Related publications (43)
A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819
Didier Trono, Gabriela Ecco, Helen Mary Rowe
Mammalian genomes are a battleground for genetic conflict between repetitive elements and KRAB-zinc finger proteins (KZFPs). We asked whether KZFPs can regulate cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR. ZP3AR coats megabase reg ...
2022Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development
Didier Trono, Evaristo Jose Planet Letschert, Shaoline Sheppard, Christopher James Playfoot
Transposable elements (TEs) contribute to the evolution of gene regulatory networks and are dynamically expressed throughout human brain development and disease. One gene regulatory mechanism influenced by TEs is the miRNA system of post-transcriptional co ...
2022KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...
2020Mild inborn errors of metabolism in commonly used inbred mouse strains
Johan Auwerx, Wei Zhang, Evan Graehl Williams
Inbred mouse strains are a cornerstone of translational research but paradoxically many strains carry mild inborn errors of metabolism. For example, alpha-aminoadipic acidemia and branched-chain ketoacid dehydrogenase deficiency are known in C57BL/6J mice. ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019Element location and classification following a damage event of a near-full-scale deployable tensegrity structure
Ian Smith, Ann Christine Sychterz
Current infrastructure is designed and built such that it must resistall possible loads. This leads to overdesigned structures that are inefficient in terms energy and cost. A structure that can self-identify damage, adapt, and learn for future events resu ...
2019DNA repair protein Rad18 restricts LINE-1 mobility
Long interspersed element-1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome. L1 utilizes an endonuclease to insert L1 cDNA into the target genomic DNA, which induces double-strand DNA breaks in the human genome and activat ...
NATURE PUBLISHING GROUP2018In and out—contribution of natural transformation to the shuffling of large genomic regions
Naturally competent bacteria can pull free DNA from their surroundings. This incoming DNA can serve various purposes, ranging from acting as a source of nutrients or DNA stretches for repair to the acquisition of novel genetic information. The latter proce ...
Elsevier2017