Concept

Cell cycle checkpoint

Related publications (343)

Protein-binding microarrays: probing disease markers at the interface of proteomics and genomics

Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod

DNA-binding proteins mediate a variety of crucial molecular functions, such as transcriptional regulation and chromosome maintenance, replication and repair, which in turn control cell division and differentiation. The roles of these proteins in disease ar ...

2009

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

Freddy Radtke, Ivan Stamenkovic

Purpose. The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro w ...

2009

IFN alpha activates dormant haematopoietic stem cells in vivo

Sandra Eloise Kjeldsen

Maintenance of the blood system is dependent on dormant haematopoietic stem cells (HSCs) with long-term self-renewal capacity. After injury these cells are induced to proliferate to quickly reestablish homeostasis(1). The signalling molecules promoting the ...

2009

Receptors of anthrax toxin and cell entry

Françoise Gisou van der Goot Grunberg

Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cell ...

Elsevier2009

Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network

Viesturs Simanis, Andrea Krapp

The protein kinase Cdc2p is the master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. It is required both for entry into mitosis and for onset of DNA replication. Cdc2p must be inactivated to permit exit from mitosis, l ...

2008

Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe

Viesturs Simanis, Andrea Krapp, Elena Cano

Cytokinesis in Schizosaccharomyces pombe begins at mitotic entry, when the site of division is defined by formation of the contractile acto-myosin ring (CAR) at the cell cortex. Contraction of the CAR and formation of the division septum are triggered at t ...

2008

A G2-phase microtubule-damage response in fission yeast

Fernando Romero Balestra

Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkp ...

Genetics Society of America2008

PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos

Pierre Gönczy, Yemima Suryani Budirahardja

Acquisition of lineage-specific cell cycle duration is an important feature of metazoan development. In Caenorhabditis elegans, differences in cell cycle duration are already apparent in two-cell stage embryos, when the larger anterior blastomere AB divide ...

2008

Characterization and Targeting of Forkhead Box K2 (FOXK2)

Forkhead/winged-helix transcription factors are evolutionarily conserved and found in organisms as diverse as yeast and humans. They regulate a broad spectrum of events during embryonic and post natal development, including cell cycle regulation, survival, ...

2008

The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways

Paul Joseph Dyson, Christian Hartinger

An investigation of the mol. mechanism of the anticancer activity demonstrated by the ruthenium(II)-arene compd. [Ru(η6-p-cymene)Cl2(pta)] (pta is 1,3,5-triaza-7-phosphaadamantane), termed "RAPTA-C", in Ehrlich ascites carcinoma (EAC) bearing mice is descr ...

2008

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