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Clostridium perfringens phospholipase C (PLC), also called alpha-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered alpha-toxin variants harboring single amino-acid substitutions in thre ...
A review with 0 refs. is presented regarding studies of a multidisciplinary team to establish the prophylactic principle and the manufg. process for anti-Rh D therapy based on recombinant antibody prepns. produced from Chinese hamster ovary cells. [on SciF ...
A review is given with 2 refs. Hemolytic disease of the newborn is an often fatal condition of some newborn babies due to the immunogenicity of their Rh D pos. erythrocytes in the Rh D neg. mother. This condition can be prevented by injecting anti-Rh D ant ...
The regulation of transferrin-receptor synthesis was studied in J2E erythroid cells induced to differentiate with erythropoietin. Nuclear run-on assays demonstrated that transcription of the transferrin-receptor gene rose markedly after erythropoietin trea ...
The NH2-terminal domain of the alpha-toxin of Clostridium perfringens is highly homologous to the complete phospholipase C from Bacillus cereus (PC-PLC), for which a high-resolution crystal structure is available. This structural information was used as th ...
The conformation of NAD bound to dogfish lactate dehydrogenase (LDH) was reinvestigated by using an NMR expt. that allows one to exploit NOEs to det. internuclear distances between pairs of protons, without perturbation of spin-diffusion effects from other ...