Concept

Fungal prion

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Fungal prion

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Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity

Structure and function of the molecular chaperone Hsp104 from yeast

Antiprion prophylaxis by gene transfer of a soluble prion antagonist

Solute energy based REMD

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host