The Chios massacre (in Η σφαγή της Χίου, i sfaˈʝi tis ˈçi.u) was a catastrophe that resulted in the death, enslavement, and flight of about four-fifths of the total population of Greeks on the island of Chios by Ottoman troops, during the Greek War of Independence in 1822. Greeks from neighboring islands had arrived on Chios and encouraged the Chiotes (the native inhabitants of the island) to join their revolt. In response, Ottoman troops landed on the island and killed thousands. The massacre of Christians provoked international outrage across the Western world, and led to increasing support for the Greek cause worldwide. For over 2,000 years, merchants and shipowners from Chios had been prominent in trade and diplomacy throughout the Black Sea, the Aegean, and the Mediterranean. The Ottoman Empire allowed Chios almost complete control over its own affairs as Chioten trade and the very highly valued mastic plant, harvested only on Chios, were of great value to the Ottomans. The cosmopolitan Chiotes were also very prominent in Constantinople. Following the massacre, however, the island never regained its commercial prominence. The island's ruling classes were reluctant to join the Greek revolt, fearing the loss of their security and prosperity. Furthermore, they were aware that they were situated far too close to the Turkish heartland in Anatolia to be safe. At some points, Chios is only from the Anatolian mainland. In March 1822, as the Greek revolt gathered strength on the mainland, several hundred armed Greeks from the neighbouring island of Samos landed in Chios. They attacked the Turks, who retreated to the citadel. Many islanders also decided to join the revolution. However, the vast majority of the population had by all accounts done nothing to provoke the reprisals, and had not joined other Greeks in their revolt against the Ottoman Empire. Reinforcements in the form of a Turkish fleet under the Kapudan Pasha Nasuhzade Ali Pasha arrived on the island on 22 March. They quickly pillaged and looted the town.