Publications related to Dementia

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Abid Oueslati

Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body formation, and neurotoxicity in vivo. However, whether phosphorylation at thes ...

2012

High b-value diffusion-weighted imaging: a sensitive method to reveal white matter differences in schizophrenia

Jean-Philippe Thiran, Reto Meuli, Pierre Marquet, Patric Hagmann, Djalel Eddine Meskaldji, Leila Cammoun, Philipp Baumann

Over the last ten years, Diffusion-weighted Imaging (DWI) has become an important tool to investigate white matter (WM) anomalies in schizophrenia. Despite technological improvement and the exponential use of this technique, discrepancies remain and little ...

Elsevier2012

Exploring the therapeutic space around NAD+

Johan Auwerx, Richardus Houtkooper

NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegenerati ...

Rockefeller University Press2012

Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

Darren Moore

There is emerging evidence implicating a role for the autophagy-ysosome pathway in the pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the brains of ...

Lippincott, Williams & Wilkins2011

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

Johannes Gräff

Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration. Cdk5 is a proline-directed serine/threonine kinase whose ac ...

Society for Neuroscience2011

Topography of EEG multivariate phase synchronization in early Alzheimer's disease

Martin Hasler, Reto Meuli, Mahdi Jalili

Alzheimer's disease (AD) is likely to disrupt the synchronization of the bioelectrical processes in the distributed cortical networks underlying cognition. We analyze the surface topography of the multivariate phase synchronization (MPS) of multichannel EE ...

2010

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

Hilal Lashuel, Abid Oueslati

A better understanding of the molecular and cellular determinants that influence the pathology of Parkinson's disease (PD) is essential for developing effective diagnostic, preventative and therapeutic strategies to treat this devastating disease. A number ...

Elsevier2010

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

Hilal Lashuel, Pierre-Alain Carrupt, Magdalena Zweckstetter, Saviana Di Giovanni, Simona Eleuteri

Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease (AD). There is considerable consensus that the increased production and/or aggregation of alpha-synuclein (alpha-syn) plays a central role in the pathogenes ...

American Society for Biochemistry and Molecular Biology2010

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

Rolf Gruetter, Tobias Kober, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques

The large spatial inhomogeneity in transmit B, field (B-1(+)) observable in human MR images at hi h static magnetic fields (B-0) severely impairs image quality. To overcome this effect in brain T-1-weighted images the, MPRAGE sequence was modified to gener ...

Elsevier2010

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Dementia

Histone acetylation: molecular mnemonics on the chromatin

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

High b-value diffusion-weighted imaging: a sensitive method to reveal white matter differences in schizophrenia

Exploring the therapeutic space around NAD+

Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

Topography of EEG multivariate phase synchronization in early Alzheimer's disease

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

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Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Exploring the therapeutic space around NAD+

Histone acetylation: molecular mnemonics on the chromatin

Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

Topography of EEG multivariate phase synchronization in early Alzheimer's disease

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

High b-value diffusion-weighted imaging: a sensitive method to reveal white matter differences in schizophrenia

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies